BRENDA - Enzyme Database

Mechanistic and structural aspects of glutathione-insulin transhydogenase (protein-disulfide interchange enzyme)

Varandani, P.T.; Dev. Biochem. 1, 29-42 (1978)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
deoxycholate
activating the enzyme membrane-bound in the microsomal fraction
Rattus norvegicus
1.8.4.2
Triton X-100
activating the enzyme membrane-bound in the microsomal fraction
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.4.2
deoxycholate
inhibitory for the solubilized enzyme
Rattus norvegicus
1.8.4.2
deoxycholate
-
Bos taurus
1.8.4.2
lysolecithin
-
Bos taurus
1.8.4.2
lysolecithin
-
Homo sapiens
1.8.4.2
lysolecithin
-
Rattus norvegicus
1.8.4.2
phosphatidic acid
-
Homo sapiens
1.8.4.2
phosphatidic acid
-
Bos taurus
1.8.4.2
phosphatidic acid
-
Rattus norvegicus
1.8.4.2
Triton X-100
inhibitory for the solubilized enzyme
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.4.2
Bos taurus
-
-
-
1.8.4.2
Homo sapiens
-
-
-
1.8.4.2
Rattus norvegicus
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
1.8.4.2
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol
random and allosteric mechanism via multiple distinct reaction sites
Bos taurus
1.8.4.2
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol
random and allosteric mechanism via multiple distinct reaction sites
Homo sapiens
1.8.4.2
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol
random and allosteric mechanism via multiple distinct reaction sites
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
heart
-
Homo sapiens
-
1.8.4.2
heart
-
Rattus norvegicus
-
1.8.4.2
heart
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
proinsulin
394811
Homo sapiens
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394811
Rattus norvegicus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394811
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + oxytoxin
-
394811
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394811
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394811
Bos taurus
?
-
-
-
?
1.8.4.2
GSH + protein disulfide
-
394811
Homo sapiens
GSSG + protein-dithiol
-
394811
Homo sapiens
?
1.8.4.2
GSH + protein disulfide
-
394811
Rattus norvegicus
GSSG + protein-dithiol
-
394811
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394811
Bos taurus
GSSG + protein-dithiol
-
394811
Bos taurus
?
1.8.4.2
GSH + vasopressin
-
394811
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394811
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394811
Bos taurus
?
-
-
-
?
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
scrambled trypsin inhibitor and proinsulin
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
scrambled trypsin inhibitor and proinsulin
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
scrambled trypsin inhibitor and proinsulin
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394811
Bos taurus
?
-
-
-
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
deoxycholate
activating the enzyme membrane-bound in the microsomal fraction
Rattus norvegicus
1.8.4.2
Triton X-100
activating the enzyme membrane-bound in the microsomal fraction
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.4.2
deoxycholate
inhibitory for the solubilized enzyme
Rattus norvegicus
1.8.4.2
deoxycholate
-
Bos taurus
1.8.4.2
lysolecithin
-
Bos taurus
1.8.4.2
lysolecithin
-
Homo sapiens
1.8.4.2
lysolecithin
-
Rattus norvegicus
1.8.4.2
phosphatidic acid
-
Homo sapiens
1.8.4.2
phosphatidic acid
-
Bos taurus
1.8.4.2
phosphatidic acid
-
Rattus norvegicus
1.8.4.2
Triton X-100
inhibitory for the solubilized enzyme
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
heart
-
Homo sapiens
-
1.8.4.2
heart
-
Rattus norvegicus
-
1.8.4.2
heart
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
proinsulin
394811
Homo sapiens
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394811
Rattus norvegicus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394811
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + oxytoxin
-
394811
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394811
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394811
Bos taurus
?
-
-
-
?
1.8.4.2
GSH + protein disulfide
-
394811
Homo sapiens
GSSG + protein-dithiol
-
394811
Homo sapiens
?
1.8.4.2
GSH + protein disulfide
-
394811
Rattus norvegicus
GSSG + protein-dithiol
-
394811
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394811
Bos taurus
GSSG + protein-dithiol
-
394811
Bos taurus
?
1.8.4.2
GSH + vasopressin
-
394811
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394811
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394811
Bos taurus
?
-
-
-
?
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
scrambled trypsin inhibitor and proinsulin
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
scrambled trypsin inhibitor and proinsulin
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
scrambled trypsin inhibitor and proinsulin
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394811
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394811
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394811
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394811
Bos taurus
?
-
-
-
-