BRENDA - Enzyme Database

Glutathione-insulin transhydrogenase (protein-disulfide interchange enzyme)

Varandani, P.T.; Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York 3, 753-765 (1989)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Homo sapiens
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Mus musculus
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Rattus norvegicus
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Bos taurus
1.8.4.2
EDTA
and other chelating agents activate
Bos taurus
1.8.4.2
EDTA
and other chelating agents activate
Homo sapiens
1.8.4.2
EDTA
and other chelating agents activate
Mus musculus
1.8.4.2
EDTA
and other chelating agents activate
Rattus norvegicus
1.8.4.2
additional information
overview
Bos taurus
1.8.4.2
additional information
overview
Homo sapiens
1.8.4.2
additional information
overview
Mus musculus
1.8.4.2
additional information
overview
Rattus norvegicus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Mus musculus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Homo sapiens
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Bos taurus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.4.2
Aprotinin
-
Bos taurus
1.8.4.2
Aprotinin
-
Homo sapiens
1.8.4.2
Aprotinin
-
Mus musculus
1.8.4.2
Aprotinin
-
Rattus norvegicus
1.8.4.2
bacitracin
-
Bos taurus
1.8.4.2
bacitracin
-
Homo sapiens
1.8.4.2
bacitracin
-
Mus musculus
1.8.4.2
bacitracin
-
Rattus norvegicus
1.8.4.2
Ca2+
slight
Homo sapiens
1.8.4.2
Ca2+
slight
Mus musculus
1.8.4.2
Ca2+
slight
Rattus norvegicus
1.8.4.2
Ca2+
slight
Bos taurus
1.8.4.2
Cu2+
-
Homo sapiens
1.8.4.2
Cu2+
-
Mus musculus
1.8.4.2
Cu2+
-
Rattus norvegicus
1.8.4.2
Cu2+
-
Bos taurus
1.8.4.2
Hg2+
-
Homo sapiens
1.8.4.2
Hg2+
-
Mus musculus
1.8.4.2
Hg2+
-
Rattus norvegicus
1.8.4.2
Hg2+
-
Bos taurus
1.8.4.2
lysolecithin
-
Mus musculus
1.8.4.2
lysolecithin
-
Bos taurus
1.8.4.2
lysolecithin
-
Homo sapiens
1.8.4.2
lysolecithin
-
Rattus norvegicus
1.8.4.2
additional information
overview
Bos taurus
1.8.4.2
additional information
overview
Homo sapiens
1.8.4.2
additional information
overview
Mus musculus
1.8.4.2
additional information
overview
Rattus norvegicus
1.8.4.2
Ni2+
slight
Bos taurus
1.8.4.2
Ni2+
slight
Homo sapiens
1.8.4.2
Ni2+
slight
Mus musculus
1.8.4.2
Ni2+
slight
Rattus norvegicus
1.8.4.2
phosphatidic acid
-
Mus musculus
1.8.4.2
phosphatidic acid
-
Homo sapiens
1.8.4.2
phosphatidic acid
-
Bos taurus
1.8.4.2
phosphatidic acid
-
Rattus norvegicus
1.8.4.2
Se2+
-
Homo sapiens
1.8.4.2
Se2+
-
Mus musculus
1.8.4.2
Se2+
-
Rattus norvegicus
1.8.4.2
Se2+
-
Bos taurus
1.8.4.2
Zn2+
-
Bos taurus
1.8.4.2
Zn2+
-
Homo sapiens
1.8.4.2
Zn2+
-
Mus musculus
1.8.4.2
Zn2+
-
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.4.2
additional information
-
additional information
-
Bos taurus
1.8.4.2
additional information
-
additional information
-
Homo sapiens
1.8.4.2
additional information
-
additional information
-
Mus musculus
1.8.4.2
additional information
-
additional information
-
Rattus norvegicus
1.8.4.2
0.01
-
Insulin
-
Bos taurus
1.8.4.2
0.01
-
Insulin
-
Homo sapiens
1.8.4.2
0.01
-
Insulin
-
Mus musculus
1.8.4.2
0.01
-
Insulin
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.4.2
endoplasmic reticulum
-
Rattus norvegicus
5783
-
1.8.4.2
membrane
bound to
Rattus norvegicus
16020
-
1.8.4.2
microsome
majority of the enzyme located at; weakly bound on cisternal surface of microsomes via phospholipids
Rattus norvegicus
-
-
1.8.4.2
secretory granule
of alpha and beta cells of islets of Langerhans
Rattus norvegicus
30141
-
1.8.4.2
zymogen granule
of acinar cells
Rattus norvegicus
42588
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.8.4.2
additional information
-
3 molecular forms: MW 56000 is the major form, MW 51000 is active and only present in spleen, possibly a proteolytic product of 56000 MW protein, MW 67000 is possibly a precursor of 56000 MW protein
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.4.2
GSH + protein disulfide
Mus musculus
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Mus musculus
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Mus musculus
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Mus musculus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.4.2
Bos taurus
-
-
-
1.8.4.2
Homo sapiens
-
-
-
1.8.4.2
Mus musculus
-
-
-
1.8.4.2
Rattus norvegicus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
1.8.4.2
phospholipoprotein
-
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
adipose tissue
-
Rattus norvegicus
-
1.8.4.2
brain
-
Rattus norvegicus
-
1.8.4.2
diaphragm
-
Rattus norvegicus
-
1.8.4.2
erythrocyte
-
Homo sapiens
-
1.8.4.2
heart
-
Mus musculus
-
1.8.4.2
heart
-
Homo sapiens
-
1.8.4.2
heart
-
Rattus norvegicus
-
1.8.4.2
heart
-
Bos taurus
-
1.8.4.2
intestine
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Mus musculus
-
1.8.4.2
kidney
-
Homo sapiens
-
1.8.4.2
kidney
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Bos taurus
-
1.8.4.2
lens
-
Rattus norvegicus
-
1.8.4.2
leukocyte
-
Homo sapiens
-
1.8.4.2
liver
-
Mus musculus
-
1.8.4.2
liver
-
Homo sapiens
-
1.8.4.2
liver
-
Bos taurus
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
lung
-
Homo sapiens
-
1.8.4.2
lung
-
Rattus norvegicus
-
1.8.4.2
additional information
-
Bos taurus
-
1.8.4.2
additional information
higher activity in mononuclear cells than in polymorphonuclear cells
Homo sapiens
-
1.8.4.2
additional information
-
Mus musculus
-
1.8.4.2
additional information
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Homo sapiens
-
1.8.4.2
pancreas
-
Mus musculus
-
1.8.4.2
pancreas
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Bos taurus
-
1.8.4.2
placenta
-
Rattus norvegicus
-
1.8.4.2
retina
-
Rattus norvegicus
-
1.8.4.2
skeletal muscle
-
Rattus norvegicus
-
1.8.4.2
spleen
-
Rattus norvegicus
-
1.8.4.2
testis
-
Rattus norvegicus
-
1.8.4.2
thymus
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.8.4.2
additional information
-
assay methods
Bos taurus
1.8.4.2
additional information
-
assay methods
Homo sapiens
1.8.4.2
additional information
-
assay methods
Mus musculus
1.8.4.2
additional information
-
assay methods
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Mus musculus
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Homo sapiens
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Rattus norvegicus
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Bos taurus
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
GSH + insulin
proinsulin
394810
Mus musculus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394810
Homo sapiens
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394810
Rattus norvegicus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394810
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + oxytoxin
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
GSH + protein disulfide
-
394810
Mus musculus
GSSG + protein-dithiol
-
394810
Mus musculus
?
1.8.4.2
GSH + protein disulfide
-
394810
Homo sapiens
GSSG + protein-dithiol
-
394810
Homo sapiens
?
1.8.4.2
GSH + protein disulfide
-
394810
Rattus norvegicus
GSSG + protein-dithiol
-
394810
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394810
Bos taurus
GSSG + protein-dithiol
-
394810
Bos taurus
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Bos taurus
?
-
-
-
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Homo sapiens
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Mus musculus
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Rattus norvegicus
1.8.4.2
Chelating agents
e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation
Bos taurus
1.8.4.2
EDTA
and other chelating agents activate
Bos taurus
1.8.4.2
EDTA
and other chelating agents activate
Homo sapiens
1.8.4.2
EDTA
and other chelating agents activate
Mus musculus
1.8.4.2
EDTA
and other chelating agents activate
Rattus norvegicus
1.8.4.2
additional information
overview
Bos taurus
1.8.4.2
additional information
overview
Homo sapiens
1.8.4.2
additional information
overview
Mus musculus
1.8.4.2
additional information
overview
Rattus norvegicus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Mus musculus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Homo sapiens
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Bos taurus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.4.2
Aprotinin
-
Bos taurus
1.8.4.2
Aprotinin
-
Homo sapiens
1.8.4.2
Aprotinin
-
Mus musculus
1.8.4.2
Aprotinin
-
Rattus norvegicus
1.8.4.2
bacitracin
-
Bos taurus
1.8.4.2
bacitracin
-
Homo sapiens
1.8.4.2
bacitracin
-
Mus musculus
1.8.4.2
bacitracin
-
Rattus norvegicus
1.8.4.2
Ca2+
slight
Homo sapiens
1.8.4.2
Ca2+
slight
Mus musculus
1.8.4.2
Ca2+
slight
Rattus norvegicus
1.8.4.2
Ca2+
slight
Bos taurus
1.8.4.2
Cu2+
-
Homo sapiens
1.8.4.2
Cu2+
-
Mus musculus
1.8.4.2
Cu2+
-
Rattus norvegicus
1.8.4.2
Cu2+
-
Bos taurus
1.8.4.2
Hg2+
-
Homo sapiens
1.8.4.2
Hg2+
-
Mus musculus
1.8.4.2
Hg2+
-
Rattus norvegicus
1.8.4.2
Hg2+
-
Bos taurus
1.8.4.2
lysolecithin
-
Mus musculus
1.8.4.2
lysolecithin
-
Bos taurus
1.8.4.2
lysolecithin
-
Homo sapiens
1.8.4.2
lysolecithin
-
Rattus norvegicus
1.8.4.2
additional information
overview
Bos taurus
1.8.4.2
additional information
overview
Homo sapiens
1.8.4.2
additional information
overview
Mus musculus
1.8.4.2
additional information
overview
Rattus norvegicus
1.8.4.2
Ni2+
slight
Bos taurus
1.8.4.2
Ni2+
slight
Homo sapiens
1.8.4.2
Ni2+
slight
Mus musculus
1.8.4.2
Ni2+
slight
Rattus norvegicus
1.8.4.2
phosphatidic acid
-
Mus musculus
1.8.4.2
phosphatidic acid
-
Homo sapiens
1.8.4.2
phosphatidic acid
-
Bos taurus
1.8.4.2
phosphatidic acid
-
Rattus norvegicus
1.8.4.2
Se2+
-
Homo sapiens
1.8.4.2
Se2+
-
Mus musculus
1.8.4.2
Se2+
-
Rattus norvegicus
1.8.4.2
Se2+
-
Bos taurus
1.8.4.2
Zn2+
-
Bos taurus
1.8.4.2
Zn2+
-
Homo sapiens
1.8.4.2
Zn2+
-
Mus musculus
1.8.4.2
Zn2+
-
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.4.2
additional information
-
additional information
-
Bos taurus
1.8.4.2
additional information
-
additional information
-
Homo sapiens
1.8.4.2
additional information
-
additional information
-
Mus musculus
1.8.4.2
additional information
-
additional information
-
Rattus norvegicus
1.8.4.2
0.01
-
Insulin
-
Bos taurus
1.8.4.2
0.01
-
Insulin
-
Homo sapiens
1.8.4.2
0.01
-
Insulin
-
Mus musculus
1.8.4.2
0.01
-
Insulin
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.4.2
endoplasmic reticulum
-
Rattus norvegicus
5783
-
1.8.4.2
membrane
bound to
Rattus norvegicus
16020
-
1.8.4.2
microsome
majority of the enzyme located at; weakly bound on cisternal surface of microsomes via phospholipids
Rattus norvegicus
-
-
1.8.4.2
secretory granule
of alpha and beta cells of islets of Langerhans
Rattus norvegicus
30141
-
1.8.4.2
zymogen granule
of acinar cells
Rattus norvegicus
42588
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.8.4.2
additional information
-
3 molecular forms: MW 56000 is the major form, MW 51000 is active and only present in spleen, possibly a proteolytic product of 56000 MW protein, MW 67000 is possibly a precursor of 56000 MW protein
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.4.2
GSH + protein disulfide
Mus musculus
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
physiological function
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Mus musculus
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
reductive degradation and assembly of proteins
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Mus musculus
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
modulation of enzymatic activity from latent to active form and vice versa
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Mus musculus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Homo sapiens
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Bos taurus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
1.8.4.2
phospholipoprotein
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
adipose tissue
-
Rattus norvegicus
-
1.8.4.2
brain
-
Rattus norvegicus
-
1.8.4.2
diaphragm
-
Rattus norvegicus
-
1.8.4.2
erythrocyte
-
Homo sapiens
-
1.8.4.2
heart
-
Mus musculus
-
1.8.4.2
heart
-
Homo sapiens
-
1.8.4.2
heart
-
Rattus norvegicus
-
1.8.4.2
heart
-
Bos taurus
-
1.8.4.2
intestine
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Mus musculus
-
1.8.4.2
kidney
-
Homo sapiens
-
1.8.4.2
kidney
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Bos taurus
-
1.8.4.2
lens
-
Rattus norvegicus
-
1.8.4.2
leukocyte
-
Homo sapiens
-
1.8.4.2
liver
-
Mus musculus
-
1.8.4.2
liver
-
Homo sapiens
-
1.8.4.2
liver
-
Bos taurus
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
lung
-
Homo sapiens
-
1.8.4.2
lung
-
Rattus norvegicus
-
1.8.4.2
additional information
-
Bos taurus
-
1.8.4.2
additional information
higher activity in mononuclear cells than in polymorphonuclear cells
Homo sapiens
-
1.8.4.2
additional information
-
Mus musculus
-
1.8.4.2
additional information
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Homo sapiens
-
1.8.4.2
pancreas
-
Mus musculus
-
1.8.4.2
pancreas
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Bos taurus
-
1.8.4.2
placenta
-
Rattus norvegicus
-
1.8.4.2
retina
-
Rattus norvegicus
-
1.8.4.2
skeletal muscle
-
Rattus norvegicus
-
1.8.4.2
spleen
-
Rattus norvegicus
-
1.8.4.2
testis
-
Rattus norvegicus
-
1.8.4.2
thymus
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.8.4.2
additional information
-
assay methods
Bos taurus
1.8.4.2
additional information
-
assay methods
Homo sapiens
1.8.4.2
additional information
-
assay methods
Mus musculus
1.8.4.2
additional information
-
assay methods
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Mus musculus
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Homo sapiens
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Rattus norvegicus
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
2,3-dimercaptopropanol + protein disulfide
-
394810
Bos taurus
2,3-dimercaptopropanol disulfide + protein-dithiol
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
cysteamine + protein disulfide
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
dihydrolipoic acid + protein disulfide
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
GSH + insulin
proinsulin
394810
Mus musculus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394810
Homo sapiens
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394810
Rattus norvegicus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + insulin
proinsulin
394810
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + oxytoxin
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + oxytoxin
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
GSH + protein disulfide
-
394810
Mus musculus
GSSG + protein-dithiol
-
394810
Mus musculus
?
1.8.4.2
GSH + protein disulfide
-
394810
Homo sapiens
GSSG + protein-dithiol
-
394810
Homo sapiens
?
1.8.4.2
GSH + protein disulfide
-
394810
Rattus norvegicus
GSSG + protein-dithiol
-
394810
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394810
Bos taurus
GSSG + protein-dithiol
-
394810
Bos taurus
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
physiological function
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
reductive degradation and assembly of proteins
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
modulation of enzymatic activity from latent to active form and vice versa
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Mus musculus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394810
Bos taurus
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Mus musculus
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Homo sapiens
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Rattus norvegicus
?
-
-
-
?
1.8.4.2
GSH + vasopressin
-
394810
Bos taurus
?
-
-
-
?
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
immunoglobulin IgM and IgG
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
scrambled lysozyme
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical
394810
Bos taurus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Mus musculus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Homo sapiens
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Rattus norvegicus
?
-
-
-
-
1.8.4.2
additional information
enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease
394810
Bos taurus
?
-
-
-
-