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Literature summary extracted from

  • Salmon-Chemin, L.; Buisine, E.; Yardley, V.; Kohler, S.; Debreu, M.A.; Landry, V.; Sergheraert, C.; Croft, S.L.; Krauth-Siegel, R.L.; Davioud-Charvet, E.
    2- And 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity (2001), J. Med. Chem., 44, 548-565.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma brucei
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Leishmania donovani
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma cruzi

Application

EC Number Application Comment Organism
1.8.1.12 medicine
-
 Trypanosoma brucei
1.8.1.12 medicine good target for structure/function studies and trypanicidal inhibitor design Trypanosoma cruzi
1.8.1.12 medicine potential target for drug design against trypanosomiasis Trypanosoma cruzi
1.8.1.12 medicine target for rational approach to design new anti-leishmanial chemotherapeutic agents Leishmania donovani

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 3,3'-[polyaminobis(carbonylalkyl)]bis(1,4-naphthoquinone) derivatives
-
 Trypanosoma cruzi
1.8.1.12 juglone
-
 Leishmania donovani
1.8.1.12 juglone
-
 Trypanosoma brucei
1.8.1.12 juglone
-
 Trypanosoma cruzi
1.8.1.12 juglone derivatives
-
 Leishmania donovani
1.8.1.12 juglone derivatives
-
 Trypanosoma brucei
1.8.1.12 juglone derivatives
-
 Trypanosoma cruzi
1.8.1.12 menadione
-
 Trypanosoma cruzi
1.8.1.12 menadione derivatives
-
 Leishmania donovani
1.8.1.12 menadione derivatives
-
 Leishmania infantum
1.8.1.12 menadione derivatives
-
 Trypanosoma brucei
1.8.1.12 menadione derivatives
-
 Trypanosoma cruzi
1.8.1.12 Plumbagin
-
 Trypanosoma brucei
1.8.1.12 Plumbagin
-
 Trypanosoma cruzi
1.8.1.12 plumbagin derivatives
-
 Leishmania donovani
1.8.1.12 plumbagin derivatives
-
 Leishmania infantum
1.8.1.12 plumbagin derivatives
-
 Trypanosoma brucei
1.8.1.12 plumbagin derivatives
-
 Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH Trypanosoma brucei
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH Leishmania donovani
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH Leishmania infantum
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH Trypanosoma cruzi
-
 trypanothione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Leishmania donovani
-
-
-
1.8.1.12 Leishmania infantum
-
-
-
1.8.1.12 Trypanosoma brucei
-
-
-
1.8.1.12 Trypanosoma cruzi P28593
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.1.12 trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ molecular modeling of inhibitor binding using X-ray data Trypanosoma cruzi
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 glutathionylspermidine disulfide + NADPH
-
 Leishmania donovani 2-glutathionylspermidine + NADP+
-
 ?
1.8.1.12 glutathionylspermidine disulfide + NADPH
-
 Trypanosoma cruzi 2-glutathionylspermidine + NADP+
-
 ?
1.8.1.12 additional information serve as subversive substrates in redox cycling activity: 3,3'-[polyaminobis(carbonylalkyl)]bis(1,4-naphthoquinone) derivatives, inhibitory and substrate activity depending on spacer length Trypanosoma cruzi ?
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma brucei trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Leishmania donovani trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Leishmania infantum trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma cruzi trypanothione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.12 TR
-
 Leishmania donovani
1.8.1.12 TR
-
 Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 FAD
-
 Trypanosoma brucei
1.8.1.12 FAD
-
 Leishmania donovani
1.8.1.12 FAD
-
 Leishmania infantum
1.8.1.12 FAD
-
 Trypanosoma cruzi
1.8.1.12 NADPH
-
 Trypanosoma brucei
1.8.1.12 NADPH
-
 Leishmania donovani
1.8.1.12 NADPH
-
 Leishmania infantum
1.8.1.12 NADPH
-
 Trypanosoma cruzi