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Literature summary extracted from
- Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase (1995), Biochem. J., 311, 371-375.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | medicine | potential target for drug design against trypanosomiasis | Crithidia fasciculata |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | acylspermines and acylspermidines | - |
Crithidia fasciculata |  |
| 1.8.1.12 | kukoamine A | mixed inhibitor | Crithidia fasciculata | |
| 1.8.1.12 | N1N8-bis(dihydrocaffeoyl)spermidine | - |
Crithidia fasciculata | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.12 | trypanothione disulfide + NADPH | Crithidia fasciculata | protection against oxidative stress | trypanothione + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.12 | Crithidia fasciculata | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.12 | trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
| 1.8.1.12 | trypanothione disulfide + NADPH | protection against oxidative stress | Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | TR | - |
Crithidia fasciculata |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | FAD | - |
Crithidia fasciculata | |
| 1.8.1.12 | NADPH | - |
Crithidia fasciculata | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.12 | 0.0018 | - |
kukoamine A | - |
Crithidia fasciculata | |
| 1.8.1.12 | 0.0075 | - |
N1N8-bis(dihydrocaffeoyl)spermidine | - |
Crithidia fasciculata | |
| 1.8.1.12 | 0.011 | 0.607 | acylspermines and acylspermidines | - |
Crithidia fasciculata | |
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