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Literature summary extracted from

  • Bond, C.S.; Zhang, Y.; Berriman, M.; Cunningham, M.L.; Fairlamb, A.H.; Hunter, W.N.
    Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors (1999), Structure, 7, 81-89.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma cruzi

Application

EC Number Application Comment Organism
1.8.1.12 medicine good target for structure/function studies and trypanicidal inhibitor design Trypanosoma cruzi

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.8.1.12 substrate binding and crystal structure in complex with trypanothione disulfide, molecular modeling with potential inhibitors Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 lunarine specific Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Trypanosoma cruzi
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.1.12 trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ substrate binding mechanism, complex structure analysis, protease-like catalytic triade and electronic induced fit Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH
-
Trypanosoma cruzi trypanothione + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.12 TR
-
Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 FAD
-
Trypanosoma cruzi
1.8.1.12 NADPH
-
Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.12 0.144
-
lunarine
-
Trypanosoma cruzi