Literature summary extracted from
Bond, C.S.; Zhang, Y.; Berriman, M.; Cunningham, M.L.; Fairlamb, A.H.; Hunter, W.N.
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors (1999), Structure, 7, 81-89.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
1.8.1.12 |
additional information |
activity is dependent on a redox-active cysteine at the active centre |
Trypanosoma cruzi |
|
Application
EC Number |
Application |
Comment |
Organism |
---|
1.8.1.12 |
medicine |
good target for structure/function studies and trypanicidal inhibitor design |
Trypanosoma cruzi |
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
1.8.1.12 |
substrate binding and crystal structure in complex with trypanothione disulfide, molecular modeling with potential inhibitors |
Trypanosoma cruzi |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.8.1.12 |
lunarine |
specific |
Trypanosoma cruzi |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.8.1.12 |
Trypanosoma cruzi |
- |
- |
- |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
1.8.1.12 |
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ |
substrate binding mechanism, complex structure analysis, protease-like catalytic triade and electronic induced fit |
Trypanosoma cruzi |
|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
1.8.1.12 |
trypanothione disulfide + NADPH |
- |
Trypanosoma cruzi |
trypanothione + NADP+ |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.8.1.12 |
TR |
- |
Trypanosoma cruzi |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
1.8.1.12 |
FAD |
- |
Trypanosoma cruzi |
|
1.8.1.12 |
NADPH |
- |
Trypanosoma cruzi |
|
Ki Value [mM]
EC Number |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Comment |
Organism |
Structure |
---|
1.8.1.12 |
0.144 |
- |
lunarine |
- |
Trypanosoma cruzi |
|