EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.12 | additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.12 | iodoacetamide | inhibition only of the enzyme with reduced cysteine residues in the catalytic center by alkylation | Crithidia fasciculata |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.12 | 0.005 | 0.007 | NADPH | - |
Crithidia fasciculata | |
1.8.1.12 | 0.053 | - |
trypanothione disulfide | - |
Crithidia fasciculata |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.8.1.12 | 53800 | - |
1 * 53800, SDS-PAGE | Crithidia fasciculata |
1.8.1.12 | 110000 | - |
enzyme cross-linked with dimethyl suberimidate, SDS-PAGE | Crithidia fasciculata |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.12 | trypanothione disulfide + NADPH | Crithidia fasciculata | - |
trypanothione + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.12 | Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.8.1.12 | - |
Crithidia fasciculata |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.8.1.12 | 284 | - |
purified enzyme | Crithidia fasciculata |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.12 | trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
1.8.1.12 | trypanothione disulfide + NADPH | highly specific for | Crithidia fasciculata | trypanothione + NADP+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.8.1.12 | dimer | 1 * 53800, SDS-PAGE | Crithidia fasciculata |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.12 | 517 | - |
trypanothione disulfide | - |
Crithidia fasciculata |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.8.1.12 | 7.5 | 8 | trypanothione disulfide + NADPH | Crithidia fasciculata |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.12 | FAD | - |
Crithidia fasciculata | |
1.8.1.12 | NADPH | - |
Crithidia fasciculata |