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Literature summary extracted from
- Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata (1987), Biochemistry, 26, 3023-3027.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.12 | additional information | - |
additional information | Km of several trypanothione disulfide derivatives, e.g. N1-monoglutathionylspermidine, mixed disulfide of N1-monoglutathionylspermidine and glutathione | Crithidia fasciculata | |
| 1.8.1.12 | 0.022 | 0.275 | glutathionylspermidine disulfide | - |
Crithidia fasciculata |  |
| 1.8.1.12 | 0.051 | - |
trypanothione disulfide | - |
Crithidia fasciculata | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.12 | Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.12 | glutathionylspermidine disulfide + NADPH | - |
Crithidia fasciculata | 2-glutathionylspermidine + NADP+ | - |
r | |
| 1.8.1.12 | additional information | reduces several trypanothione derivatives, e.g. N1-monoglutathionylspermidine, mixed disulfide of N1-monoglutathionylspermidine and glutathione | Crithidia fasciculata | ? | - |
? | |
| 1.8.1.12 | trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
r | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.12 | 27 | - |
assay at | Crithidia fasciculata |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.12 | 7.8 | - |
- |
Crithidia fasciculata |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | FAD | - |
Crithidia fasciculata | |
| 1.8.1.12 | NADPH | - |
Crithidia fasciculata | |
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Release 2023.1 (January 2023)
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