Literature summary extracted from

Shames, S.L.; Kimmel, B.E.; Peoples, O.P.; Agabian, N.; Walsh, C.T.
Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase (1988), Biochemistry, 27, 5014-5019.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.8.1.12	additional information	activity is dependent on a redox-active cysteine at the active centre	Trypanosoma congolense

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.8.1.12	DNA sequence analysis	Trypanosoma congolense

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.8.1.12	53443	-	2 * 53443, DNA sequence	Trypanosoma congolense

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.12	Trypanosoma congolense	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.1.12	trypanothione disulfide + NADPH	-	Trypanosoma congolense	trypanothione + NADP+	-	r

Subunits

EC Number	Subunits	Comment	Organism
1.8.1.12	dimer	2 * 53443, DNA sequence	Trypanosoma congolense

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.8.1.12	FAD	-	Trypanosoma congolense
1.8.1.12	NADPH	-	Trypanosoma congolense

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Release 2023.1 (January 2023)