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Literature summary extracted from

  • Henderson, G.B.; Ulrich, P.; Fairlamb, A.H.; Rosenberg, I.; Pereira, M.; Sela, M.; Cerami, A.
    Subversive substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease (1988), Proc. Natl. Acad. Sci. USA, 85, 5374-5378.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Crithidia fasciculata
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma cruzi

Application

EC Number Application Comment Organism
1.8.1.12 medicine inhibition of the enzyme by naphthoquinone and nitrofuran derivatives abolish the cell penetration by the parasite trypomasstigotes, alternate approach to chemotherapy of trypanosomiasis and leishmaniasis, Chagas' disease Crithidia fasciculata
1.8.1.12 medicine inhibition of the enzyme by naphthoquinone and nitrofuran derivatives abolish the cell penetration by the parasite trypomasstigotes, alternate approach to chemotherapy of trypanosomiasis and leishmaniasis, Chagas' disease Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 nifurtimox
-
 Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH Crithidia fasciculata
-
 trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH Trypanosoma cruzi
-
 trypanothione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Crithidia fasciculata
-
 insect-parasitic trypanosomatid
-
1.8.1.12 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 additional information naphthoquinones and nitrofuran derivatives are reduced, inhibition of the enzyme Crithidia fasciculata ?
-
 ?
1.8.1.12 additional information naphthoquinones and nitrofuran derivatives are reduced, inhibition of the enzyme Trypanosoma cruzi ?
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Crithidia fasciculata trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Crithidia fasciculata trypanothione + NADP+
-
 r
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma cruzi trypanothione + NADP+
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma cruzi trypanothione + NADP+
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.1.12 27
-
 assay at Crithidia fasciculata
1.8.1.12 27
-
 assay at Trypanosoma cruzi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.1.12 7.8
-
 assay at Crithidia fasciculata
1.8.1.12 7.8
-
 assay at Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 FAD
-
 Crithidia fasciculata
1.8.1.12 FAD
-
 Trypanosoma cruzi
1.8.1.12 NADPH
-
 Crithidia fasciculata
1.8.1.12 NADPH
-
 Trypanosoma cruzi