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Literature summary extracted from

  • Taylor, M.C.; Chapman, C.J.; Kelly, J.M.; Fairlamb, A.H.; Miles, M.A.
    Cloning by expression of a cDNA corresponding to Leishmania donovani trypanothione reductase (1989), Biochem. Soc. Trans., 17, 579-580.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma brucei
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Crithidia fasciculata
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Leishmania donovani
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma cruzi
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma congolense
1.8.1.12 additional information activity is dependent on a redox-active cysteine at the active centre Leishmania aethiopica

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.1.12 single copy gene Leishmania donovani

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Crithidia fasciculata
-
 insect-parasitic trypanosomatid
-
1.8.1.12 Leishmania aethiopica
-
-
-
1.8.1.12 Leishmania donovani
-
-
-
1.8.1.12 Trypanosoma brucei
-
-
-
1.8.1.12 Trypanosoma congolense
-
-
-
1.8.1.12 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma brucei trypanothione + NADP+
-
 r
1.8.1.12 trypanothione disulfide + NADPH
-
 Crithidia fasciculata trypanothione + NADP+
-
 r
1.8.1.12 trypanothione disulfide + NADPH
-
 Leishmania donovani trypanothione + NADP+
-
 r
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma cruzi trypanothione + NADP+
-
 r
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma congolense trypanothione + NADP+
-
 r
1.8.1.12 trypanothione disulfide + NADPH
-
 Leishmania aethiopica trypanothione + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.8.1.12 ? x * 50000-55000, SDS-PAGE, immunostaining Trypanosoma brucei
1.8.1.12 ? x * 50000-55000, SDS-PAGE, immunostaining Crithidia fasciculata
1.8.1.12 ? x * 50000-55000, SDS-PAGE, immunostaining Leishmania donovani
1.8.1.12 ? x * 50000-55000, SDS-PAGE, immunostaining Trypanosoma cruzi
1.8.1.12 ? x * 50000-55000, SDS-PAGE, immunostaining Leishmania aethiopica

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 FAD
-
 Trypanosoma brucei
1.8.1.12 FAD
-
 Crithidia fasciculata
1.8.1.12 FAD
-
 Leishmania donovani
1.8.1.12 FAD
-
 Trypanosoma cruzi
1.8.1.12 FAD
-
 Trypanosoma congolense
1.8.1.12 FAD
-
 Leishmania aethiopica
1.8.1.12 NADP+
-
 Trypanosoma brucei
1.8.1.12 NADP+
-
 Crithidia fasciculata
1.8.1.12 NADP+
-
 Leishmania donovani
1.8.1.12 NADP+
-
 Trypanosoma cruzi
1.8.1.12 NADP+
-
 Trypanosoma congolense
1.8.1.12 NADP+
-
 Leishmania aethiopica
1.8.1.12 NADPH
-
 Trypanosoma brucei
1.8.1.12 NADPH
-
 Crithidia fasciculata
1.8.1.12 NADPH
-
 Leishmania donovani
1.8.1.12 NADPH
-
 Trypanosoma cruzi
1.8.1.12 NADPH
-
 Trypanosoma congolense
1.8.1.12 NADPH
-
 Leishmania aethiopica