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Literature summary extracted from
- A NADPH:glutathione oxidoreductase isolated from Thiobacillus thiooxidans (1976), Agric. Biol. Chem., 40, 1879-1880.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | AgNO3 | - |
Acidithiobacillus thiooxidans |  |
| 1.8.1.7 | Hg2+ | - |
Acidithiobacillus thiooxidans | |
| 1.8.1.7 | mercuric sulfate | - |
Acidithiobacillus thiooxidans | |
| 1.8.1.7 | p-chloromercuribenzoate | - |
Acidithiobacillus thiooxidans | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.7 | cytoplasm | - |
Acidithiobacillus thiooxidans | 5737 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Acidithiobacillus thiooxidans | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.1.7 | - |
Acidithiobacillus thiooxidans |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 0.331 | - |
purified enzyme | Acidithiobacillus thiooxidans |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | GSSG + NADPH | methylene blue and L-cystine slowly | Acidithiobacillus thiooxidans | glutathione + NADP+ | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 45 | - |
irreversible denaturation above, complete loss of activity after 40 min | Acidithiobacillus thiooxidans |
| 1.8.1.7 | 50 | - |
10 min, complete loss of activity | Acidithiobacillus thiooxidans |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 7 | - |
- |
Acidithiobacillus thiooxidans |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 6 | 8 | unstable below and above | Acidithiobacillus thiooxidans |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | NADH | low activity with NADH | Acidithiobacillus thiooxidans | |
| 1.8.1.7 | NADPH | - |
Acidithiobacillus thiooxidans | |
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Release 2023.1 (January 2023)
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