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Literature summary extracted from
- beta-Cyclopiazonate oxidocyclase from Penicillium cyclopium. II. Studies on electron acceptors, inhibitors, enzyme kinetics, amino acid composition, flavin prosthetic group and other properties (1971), Biochim. Biophys. Acta, 250, 329-345.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.99.1 | Co2+ | - |
Penicillium cyclopium |  |
| 1.21.99.1 | Cu2+ | - |
Penicillium cyclopium | |
| 1.21.99.1 | Hg2+ | - |
Penicillium cyclopium | |
| 1.21.99.1 | Mn2+ | - |
Penicillium cyclopium | |
| 1.21.99.1 | Zn2+ | - |
Penicillium cyclopium | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.21.99.1 | 0.00016 | - |
2,6-dichlorophenolindophenol | - |
Penicillium cyclopium | |
| 1.21.99.1 | 0.0021 | 0.014 | beta-Cyclopiazonate | - |
Penicillium cyclopium | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.99.1 | beta-cyclopiazonate + acceptor | Penicillium cyclopium | acceptors: 2,6-dichlorophenolindophenol, cytochrome c, phenazine methosulfate, oxygen, cyclopiazonate is a microbial toxin | alpha-cyclopiazonate + reduced acceptor | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.21.99.1 | Penicillium cyclopium | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.99.1 | beta-cyclopiazonate + 2,6-dichlorophenolindophenol | - |
Penicillium cyclopium | alpha-cyclopiazonate + reduced 2,6-dichlorophenolindophenol | - |
r | |
| 1.21.99.1 | beta-cyclopiazonate + acceptor | acceptors: 2,6-dichlorophenolindophenol, cytochrome c, phenazine methosulfate, oxygen, cyclopiazonate is a microbial toxin | Penicillium cyclopium | alpha-cyclopiazonate + reduced acceptor | - |
ir | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.21.99.1 | 6.8 | - |
beta-cyclopiazonate + 2,6-dichlorophenolindophenol | Penicillium cyclopium |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.99.1 | FAD | - |
Penicillium cyclopium | |
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Release 2023.1 (January 2023)
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