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Literature summary extracted from

  • Houslay, M.D.; Tipton, K.F.
    A kinetic evaluation of monoamine oxidase activity in rat liver mitochondrial outer membranes (1974), Biochem. J., 139, 645-652.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 4-Cyanophenol
-
 Rattus norvegicus
1.4.3.4 benzyl cyanide reversible inhibitor Rattus norvegicus
1.4.3.4 Clorgyline MAO-A highly sensitive and MAO-B less sensitive to inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information
-
 Rattus norvegicus
1.4.3.4 0.0159
-
 5-methoxytryptamine
-
 Rattus norvegicus
1.4.3.4 0.0185
-
 tryptamine
-
 Rattus norvegicus
1.4.3.4 0.0208
-
 2-Phenylethylamine
-
 Rattus norvegicus
1.4.3.4 0.0238
-
 4-methoxy-2-phenylethylamine
-
 Rattus norvegicus
1.4.3.4 0.187
-
 5-hydroxytryptamine
-
 Rattus norvegicus
1.4.3.4 0.245
-
 benzylamine
-
 Rattus norvegicus
1.4.3.4 0.282
-
 tyramine
-
 Rattus norvegicus
1.4.3.4 0.405
-
 dopamine
-
 Rattus norvegicus
1.4.3.4 0.475
-
 4-hydroxy-3-methoxy-2-phenylethylamine
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrial outer membrane
-
 Rattus norvegicus 5741
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 2-phenylethylamine + H2O + O2
-
 Rattus norvegicus 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 4-hydroxy-3-methoxy-2-phenylethylamine + H2O + O2
-
 Rattus norvegicus ?
-
 r
1.4.3.4 4-methoxy-2-phenylethylamine + H2O + O2
-
 Rattus norvegicus ?
-
 r
1.4.3.4 benzylamine + H2O + O2
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 dopamine + H2O + O2
-
 Rattus norvegicus (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 methoxytryptamine + H2O + O2
-
 Rattus norvegicus ?
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 specificity Rattus norvegicus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 5-hydroxytryptamine, MAO-A selective substrate Rattus norvegicus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 4-hydroxy-3-methoxy-2-phenylethylamine, nonselective substrate, 4-methoxy-2-phenylethylamine, 5-methoxytryptamine Rattus norvegicus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + H2O + O2
-
 Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tryptamine + H2O + O2
-
 Rattus norvegicus 1-H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 More MAO-A and MAO-B are 2 different isoenzymic forms which differ in substrate specificity, distribution among tissues and their structures Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 9.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.4.3.4 additional information
-
 lability increased at pH-values greater than 10 Rattus norvegicus