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Literature summary extracted from

  • Sanchez, L.B.; Elmendorf, H.; Nash, T.E.; Muller, M.
    NAD(P)H:menadione oxidoreductase of the amitochondriate eukaryote Giardia lamblia: a simpler homologue of the vertebrate enzyme (2001), Microbiology, 147, 561-570.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.5.2 expression in Escherichia coli Giardia intestinalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 1,10-phenanthroline
-
Giardia intestinalis
1.6.5.2 3,3'-methylene-bis(4-hydroxycoumarin)
-
Giardia intestinalis
1.6.5.2 N-ethylmaleimide
-
Giardia intestinalis
1.6.5.2 quercetin
-
Giardia intestinalis
1.6.5.2 quinacrine dihydrochloride 0.05 mM, 65-95% inhibition depending on substrate Giardia intestinalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.5.2 0.000188
-
menadione cofactor NADH Giardia intestinalis
1.6.5.2 0.00024
-
menadione cofactor NADPH Giardia intestinalis
1.6.5.2 0.000437
-
naphthoquinone cofactor NADH Giardia intestinalis
1.6.5.2 0.00059
-
naphthoquinone cofactor NADPH Giardia intestinalis
1.6.5.2 0.03
-
NADPH reduction of menadione Giardia intestinalis
1.6.5.2 0.033
-
NADPH reduction of naphthoquinone Giardia intestinalis
1.6.5.2 0.045
-
NADH reduction of naphthoquinone Giardia intestinalis
1.6.5.2 0.549
-
NADH reduction of menadione Giardia intestinalis

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Giardia intestinalis
-
amitochondriate eukaryote
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.5.2 recombinant enzyme Giardia intestinalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 1,4-naphthoquinone + NAD(P)H
-
Giardia intestinalis 1,4-naphthohydroquinone + NAD(P)+
-
?
1.6.5.2 2-methyl-1,4-naphthoquinone + NAD(P)H
-
Giardia intestinalis 2-methyl-1,4-naphthoquinol + NAD(P)+
-
?
1.6.5.2 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide + NAD(P)H
-
Giardia intestinalis reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide + NAD(P)+
-
?
1.6.5.2 K3[Fe(CN)6] + NAD(P)H
-
Giardia intestinalis K4[Fe(CN)6] + NAD(P)+
-
?
1.6.5.2 menadione + NADH + H+
-
Giardia intestinalis menadiol + NAD+
-
r
1.6.5.2 methyl red + NAD(P)H
-
Giardia intestinalis reduced methyl red + NAD(P)+
-
?
1.6.5.2 naphthoquinone + NADH + H+
-
Giardia intestinalis naphthoquinol + NAD+
-
r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6.5.2 23.1
-
menadione cofactor NADH Giardia intestinalis
1.6.5.2 29.9
-
naphthoquinone cofactor NADH Giardia intestinalis
1.6.5.2 31.7
-
NADH reduction of menadione Giardia intestinalis
1.6.5.2 34.8
-
menadione cofactor NADPH Giardia intestinalis
1.6.5.2 39.3
-
naphthoquinone cofactor NADPH Giardia intestinalis
1.6.5.2 47.5
-
NADPH reduction of naphthoquinone Giardia intestinalis
1.6.5.2 52.7
-
NADPH reduction of menadione Giardia intestinalis
1.6.5.2 62.7
-
NADH reduction of naphthoquinone Giardia intestinalis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6.5.2 0.00095
-
dicoumarol cofactor NADH Giardia intestinalis
1.6.5.2 0.00109
-
dicoumarol cofactor NADH Giardia intestinalis
1.6.5.2 0.00412
-
dicoumarol cofactor NADPH Giardia intestinalis
1.6.5.2 0.00511
-
dicoumarol cofactor NADPH Giardia intestinalis