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Literature summary extracted from

  • Chen, S.; Knox, R.; Lewis, A.D.; Friedlos, F.; Workman, P.; Deng, P.S.K.; Fung, M.; Ebenstein, D.; Wu, K.; Tsai, T.M.
    Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes (1995), Mol. Pharmacol., 47, 934-939.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.6.5.2 medicine activation of antitumor prodrugs Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.5.2
-
 Mus musculus
1.6.5.2
-
 Homo sapiens
1.6.5.2
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 3,3'-methylene-bis(4-hydroxycoumarin)
-
 Homo sapiens
1.6.5.2 3,3'-methylene-bis(4-hydroxycoumarin)
-
 Mus musculus
1.6.5.2 3,3'-methylene-bis(4-hydroxycoumarin)
-
 Rattus norvegicus
1.6.5.2 5,7-dihydroxyflavone
-
 Homo sapiens
1.6.5.2 5,7-dihydroxyflavone
-
 Mus musculus
1.6.5.2 5,7-dihydroxyflavone
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.5.2 0.025
-
 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione
-
 Homo sapiens
1.6.5.2 0.027
-
 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione
-
 Rattus norvegicus
1.6.5.2 0.04
-
 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione
-
 Mus musculus
1.6.5.2 0.1
-
 NADH
-
 Homo sapiens
1.6.5.2 0.11
-
 NADH
-
 Rattus norvegicus
1.6.5.2 0.12
-
 NADH
-
 Mus musculus
1.6.5.2 0.84
-
 5-(aziridin-1-yl)-4-hydroxylamino-2-benzamide
-
 Rattus norvegicus
1.6.5.2 1.28
-
 5-(aziridin-1-yl)-4-hydroxylamino-2-benzamide
-
 Mus musculus
1.6.5.2 1.37
-
 5-(aziridin-1-yl)-4-hydroxylamino-2-benzamide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Homo sapiens
-
-
-
1.6.5.2 Mus musculus
-
-
-
1.6.5.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.5.2 recombinant enzyme Mus musculus
1.6.5.2 recombinant enzyme Homo sapiens
1.6.5.2 recombinant enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 2-methyl-1,4-naphthoquinone + NAD(P)H
-
 Mus musculus 2-methyl-1,4-naphthoquinol + NAD(P)+
-
 ?
1.6.5.2 2-methyl-1,4-naphthoquinone + NAD(P)H
-
 Rattus norvegicus 2-methyl-1,4-naphthoquinol + NAD(P)+
-
 ?
1.6.5.2 2-methyl-1,4-naphthoquinone + NAD(P)H involved in the process of reductive activation of several cytotoxic antitumor quinones, such as mitomycins, anthracyclines and azaridinylbenzoquinones Homo sapiens 2-methyl-1,4-naphthoquinol + NAD(P)+
-
 ?
1.6.5.2 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione + NAD(P)H
-
 Mus musculus 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-diol + NAD(P)+
-
 ?
1.6.5.2 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione + NAD(P)H
-
 Homo sapiens 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-diol + NAD(P)+
-
 ?
1.6.5.2 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione + NAD(P)H
-
 Rattus norvegicus 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-diol + NAD(P)+
-
 ?
1.6.5.2 5-(aziridin-1-yl)-2,4-dinitrobenzamide + NAD(P)H
-
 Mus musculus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + NAD(P)+
-
 ?
1.6.5.2 5-(aziridin-1-yl)-2,4-dinitrobenzamide + NAD(P)H
-
 Homo sapiens 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + NAD(P)+
-
 ?
1.6.5.2 5-(aziridin-1-yl)-2,4-dinitrobenzamide + NAD(P)H
-
 Rattus norvegicus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + NAD(P)+
-
 ?
1.6.5.2 5-(aziridin-1-yl)-2,4-dinitrobenzamide + reduced dihydronicotineamide riboside
-
 Mus musculus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + oxidized dihydronicotineamide riboside
-
 ?
1.6.5.2 5-(aziridin-1-yl)-2,4-dinitrobenzamide + reduced dihydronicotineamide riboside
-
 Homo sapiens 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + oxidized dihydronicotineamide riboside
-
 ?
1.6.5.2 5-(aziridin-1-yl)-2,4-dinitrobenzamide + reduced dihydronicotineamide riboside
-
 Rattus norvegicus 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide + oxidized dihydronicotineamide riboside
-
 ?
1.6.5.2 menadione + NADH + H+
-
 Mus musculus menadiol + NAD+
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6.5.2 0.07
-
 5,7-dihydroxyflavone
-
 Homo sapiens
1.6.5.2 0.08
-
 5,7-dihydroxyflavone
-
 Rattus norvegicus
1.6.5.2 0.68
-
 5,7-dihydroxyflavone
-
 Mus musculus