Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Deng, Y.; Wang, Z.; Ying, K.; Gu, S.; Ji, C.; Huang, Y.; Gu, X.; Wang, Y.; Xu, Y.; Li, Y.; Xie, Y.; Mao, Y.
    NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties (2002), Int. J. Biochem. Cell Biol., 34, 1035-1050.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.7.1.7 additional information no sulfhydryl donor required for activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.7.1.7 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.7.1.7 Ca2+ 1 mM, 49% inhibition Homo sapiens
1.7.1.7 Cu2+ 1 mM, more than 90% inhibition Homo sapiens
1.7.1.7 GTP 0.05 mM, 30% inhibition Homo sapiens
1.7.1.7 Mg2+ 1 mM, 9% inhibition Homo sapiens
1.7.1.7 additional information not inhibited by ATP Homo sapiens
1.7.1.7 Ni2+ 1 mM, more than 90% inhibition Homo sapiens
1.7.1.7 XMP 0.05 mM, 99% inhibition Homo sapiens
1.7.1.7 XTP 0.05 mM, 50% inhibition Homo sapiens
1.7.1.7 Zn2+ 1 mM, 86% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.7.1.7 0.0174
-
 GMP
-
 Homo sapiens
1.7.1.7 0.0266
-
 NADPH
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.7.1.7 40000
-
 x * 40000, recombinant His-tagged enzyme, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.7.1.7 Homo sapiens
-
-
-
1.7.1.7 Homo sapiens Q9P2T1
-
-
1.7.1.7 no activity in Haemophilus influenzae
-
-
-
1.7.1.7 no activity in Methanocaldococcus jannaschii
-
 other name Methanococcus jannaschii
-
1.7.1.7 no activity in Mycoplasma genitalium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.7.1.7 recombinant His-tagged enzyme Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.7.1.7 brain strong expression Homo sapiens
-
1.7.1.7 cardiac muscle
-
 Homo sapiens
-
1.7.1.7 colon expressed at low levels Homo sapiens
-
1.7.1.7 kidney
-
 Homo sapiens
-
1.7.1.7 leukocyte expressed at low levels Homo sapiens
-
1.7.1.7 liver strong expression Homo sapiens
-
1.7.1.7 placenta strong expression Homo sapiens
-
1.7.1.7 skeletal muscle
-
 Homo sapiens
-
1.7.1.7 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.1.7 NADPH + guanosine 5'-phosphate
-
 Homo sapiens NADP+ + inosine 5'-phosphate + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
1.7.1.7 ? x * 40000, recombinant His-tagged enzyme, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.7.1.7 7.1
-
 enzyme shows 2 maxima Homo sapiens
1.7.1.7 7.8
-
 enzyme shows 2 maxima, strong decrease above Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.7.1.7 7 8.2 strong decrease above Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.7.1.7 NADPH
-
 Homo sapiens
1.7.1.7 NADPH no activity with NADH Homo sapiens