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Literature summary extracted from

  • Umeki, S.
    Prostaglandin E1 and analogs of prostacyclin influencing superoxide production by the human neutrophil NADPH oxidase system (1994), Int. J. Biochem., 26, 1003-1008.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 sodiumdodecylsulfate
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 15-cis-(4-propyl-cyclohexyl)-16,17,18,19,20-pentanor-9-deoxy-9alpha,6-nitrilo-prostaglandin F1 methyl ester 0.021 mM, 50% inhibition of the enzyme in neutrophils possible due to scavenging of O2-, inhibition of SDS-induced activation in cell free extracts, 0.22 mM, 50% inhibition Homo sapiens
1.6.3.1 5-(E)-6,9-deoxa-6,9alpha-methylene-15-cyclopentyl-16,17,18,19,20-pentanor-prostaglandin I2 inhibition of sodiumdodecylsulfate-induced activation in cell free extracts, 0.17 mM, 50% inhibition Homo sapiens
1.6.3.1 prostaglandin E1 inhibition of sodiumdodecylsulfate-induced activation in cell free extracts, 0.044 mM, 50% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.3.1 0.04
-
 NADPH
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.1 NADPH + O2 Homo sapiens enzyme is stimulated by phagocytizable particles NADP+ + O2-
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Homo sapiens
-
 multienzyme complex
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NADPH + O2 enzyme is stimulated by phagocytizable particles Homo sapiens NADP+ + O2-
-
 ?