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Literature summary extracted from
- Properties and biochemical characterization of NADH 5alpha-reductase from rat liver microsomes (1985), Biol. Chem. Hoppe-Seyler, 366, 647-653.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.6.2.2 | inactivation caused by solubilization with detergents, activity restored by phosphatidylcholine | Rattus norvegicus |
| 1.6.2.2 | phosphate stabilizes | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.6.2.2 | 5'-(p-fluorosulfonylbenzoyl)-adenosine | - |
Rattus norvegicus |  |
| 1.6.2.2 | Amytal | - |
Rattus norvegicus | |
| 1.6.2.2 | dicoumarol | - |
Rattus norvegicus | |
| 1.6.2.2 | Mepacrin | - |
Rattus norvegicus | |
| 1.6.2.2 | NADP+ | - |
Rattus norvegicus | |
| 1.6.2.2 | Pentachlorophenol | - |
Rattus norvegicus | |
| 1.6.2.2 | Thenoyltrifluoroacetone | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.6.2.2 | 0.025 | 0.089 | testosterone | depending on phosphate concentration | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.6.2.2 | endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.6.2.2 | 5alpha-dihydrotestosterone + acceptor | Rattus norvegicus | - |
? | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.6.2.2 | Rattus norvegicus | - |
antibodies against the liver enzyme activate NADH 5-alpha reductase | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.6.2.2 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.6.2.2 | 2 ferricytochrome b5 + NADH | - |
Rattus norvegicus | 2 ferrocytochrome b5 + NAD+ + H+ | - |
? | |
| 1.6.2.2 | 5alpha-dihydrotestosterone + acceptor | - |
Rattus norvegicus | ? | - |
r | |
| 1.6.2.2 | NADH + testosterone | - |
Rattus norvegicus | ? | - |
r | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.6.2.2 | NADH | - |
Rattus norvegicus | |
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