EC Number | Cloned (Comment) | Organism |
---|---|---|
1.8.4.11 | expression of GFP-tagged wild-type MsrA and several GFP-tagged deletion mutants in several mammalian cell lines, overview, expression of His-tagged wild-type and DELTA(1-22) deletion mutant in Escherichia coli strain M15 | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.8.4.11 | mitochondrion | MsrA contains a mitochondrial targeting sequence which is not necessary for catalytic activity | Homo sapiens | 5739 | - |
1.8.4.11 | additional information | subcellular localization analysis, the subcellular localization is not tissue-dependent | Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | Homo sapiens | stereospecific reduction, the enzyme is involved in repair of oxidized proteins | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.4.11 | Homo sapiens | Q9UJ68 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.8.4.11 | recombinant His-tagged wild-type and DELTA(1-22) deletion mutant from Escherichia coli strain M15 by nickel affinity chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Homo sapiens | peptide-L-methionine + DTT disulfide + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction, the enzyme is involved in repair of oxidized proteins | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.4.11 | MsrA | - |
Homo sapiens |
1.8.4.11 | peptide methionine sulfoxide reductase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.8.4.11 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.8.4.11 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.11 | dithiothreitol | - |
Homo sapiens | |
1.8.4.11 | thioredoxin | - |
Homo sapiens |