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Literature summary extracted from

  • Argyrou, A.; Blanchard, J.S.
    Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes (2001), Biochemistry, 40, 11353-11363.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.1.4 expression in Escherichia coli Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.4 0.0041
-
NADH reaction with thio-NAD+ Mycobacterium tuberculosis
1.8.1.4 0.0073
-
NADH
-
Mycobacterium tuberculosis
1.8.1.4 0.0084
-
NADH reaction with O2 Mycobacterium tuberculosis
1.8.1.4 0.036
-
thio-NAD+ reaction with NADH Mycobacterium tuberculosis
1.8.1.4 0.11
-
thio-NADH
-
Mycobacterium tuberculosis
1.8.1.4 0.156
-
NADH reaction with 2,6-dimethyl-1,4-benzoquinone Mycobacterium tuberculosis
1.8.1.4 0.161
-
NADH reaction with 5-hydroxy-1,4-naphthoquinone Mycobacterium tuberculosis
1.8.1.4 0.29
-
5-hydroxy-1,4-naphthoquinone
-
Mycobacterium tuberculosis
1.8.1.4 0.39
-
3-acetylpyridine adenine dinucleotide
-
Mycobacterium tuberculosis
1.8.1.4 0.56
-
Lipoamide reaction with 3-acetylpyridine adenine dinucleotide Mycobacterium tuberculosis
1.8.1.4 0.86
-
2,6-dimethyl-1,4-benzoquinone
-
Mycobacterium tuberculosis
1.8.1.4 2.6
-
nicotinamide hypoxanthine dinucleotide
-
Mycobacterium tuberculosis
1.8.1.4 5.8
-
Lipoamide reaction with thio-NADH Mycobacterium tuberculosis
1.8.1.4 6.4
-
Lipoamide reaction with nicotinamide hypoxanthine dinucleotide Mycobacterium tuberculosis
1.8.1.4 16
-
Lipoamide reaction with NADH Mycobacterium tuberculosis
1.8.1.4 120
-
lipoate
-
Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.4 recombinant enzyme Mycobacterium tuberculosis

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.1.4 protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+ ping-pong mechanism Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.4 2,6-dimethyl-1,4-benzoquinone + NADH
-
Mycobacterium tuberculosis 2,6-dimethyl-1,4-benzoquinol + NAD+
-
?
1.8.1.4 5-hydroxy-1,4-naphthoquinone + NADH
-
Mycobacterium tuberculosis 5-hydroxy-1,4-naphthoquinol + NAD+
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Mycobacterium tuberculosis lipoamide + NADH
-
?
1.8.1.4 lipoamide + 3-acetylpyridine adenine dinucleotide
-
Mycobacterium tuberculosis dihydrolipoamide + ?
-
?
1.8.1.4 lipoamide + nicotinamide hypoxanthine dinucleotide
-
Mycobacterium tuberculosis dihydrolipoamide + ?
-
?
1.8.1.4 lipoamide + thio-NADH
-
Mycobacterium tuberculosis dihydrolipoamide + thio-NAD+
-
?
1.8.1.4 lipoic acid + NADH
-
Mycobacterium tuberculosis dihydrolipoic acid + NAD+
-
?
1.8.1.4 additional information reductive half-reaction, hydride transfer from NADH to FAD, is rate limiting when a quinone is the oxidant Mycobacterium tuberculosis ?
-
?
1.8.1.4 O2 + NADH
-
Mycobacterium tuberculosis ?
-
?
1.8.1.4 thio-NAD+ + NADH
-
Mycobacterium tuberculosis thio-NADH + NAD+
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.1.4 additional information
-
additional information
-
Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.4 NAD+
-
Mycobacterium tuberculosis
1.8.1.4 NADH
-
Mycobacterium tuberculosis