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Literature summary extracted from

  • Williams, C.H.
    Flavin-containing dehydrogenases (1976), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 13, 89-173.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.9 phosphate 2fold activation Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 Cu2+ no inhibition Homo sapiens
1.8.1.7 glutathione product inhibition Homo sapiens
1.8.1.7 N-ethylmaleimide
-
Saccharomyces cerevisiae
1.8.1.7 NADP+
-
Homo sapiens
1.8.1.7 NADP+
-
Rattus norvegicus
1.8.1.7 NADP+
-
Saccharomyces cerevisiae
1.8.1.7 NADPH
-
Homo sapiens
1.8.1.7 p-chloromercuriphenyl sulfonate
-
Saccharomyces cerevisiae
1.8.1.7 phenyl mercuric acetate
-
Saccharomyces cerevisiae
1.8.1.7 phosphate buffer
-
Homo sapiens
1.8.1.9 NADP+ product inhibition Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.7 0.0038
-
NADPH
-
Saccharomyces cerevisiae
1.8.1.7 0.0095
-
NADPH 0.03 M phosphate buffer Homo sapiens
1.8.1.7 0.013
-
NADPH 0.3 M phosphate buffer Homo sapiens
1.8.1.7 0.019
-
GSSG 0.03 M phosphate buffer Homo sapiens
1.8.1.7 0.055
-
GSSG
-
Saccharomyces cerevisiae
1.8.1.7 0.125
-
GSSG 0.3 M phosphate buffer Homo sapiens
1.8.1.9 0.0008
-
NADPH at 4°C Escherichia coli
1.8.1.9 0.0012
-
NADPH at 25°C Escherichia coli
1.8.1.9 0.0017
-
thioredoxin at 4°C Escherichia coli
1.8.1.9 0.0028
-
thioredoxin at 25°C Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.7 mitochondrion cytoplasm-like spaces of mitochondria Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.9 66000
-
sedimentation equilibrium analysis Escherichia coli
1.8.1.9 73000 75000 amino acid analysis based on 2 mol FAD per molecule of enzyme Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.7 GSSG + NADPH Homo sapiens
-
glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Saccharomyces cerevisiae
-
glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Hemicentrotus pulcherrimus
-
glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Escherichia coli production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Rattus norvegicus production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Rattus norvegicus production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 glutathione + NADP+
-
ir
1.8.1.7 GSSG + NADPH Penicillium chrysogenum production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Escherichia coli B / ATCC 11303 production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Escherichia coli Crookes production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH Escherichia coli M191-6 production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 glutathione + NADP+
-
?
1.8.1.9 thioredoxin + NADP+ Escherichia coli metabolic function of thioredoxin reductase-thioredoxin system: supplies reducing equivalents for a wide variety of acceptors, e.g. : ribonucleotide reductase, nonspecific protein disulfide reductase, methionine sulfoxide reductase, D-proline reductase thioredoxin disulfide + NADPH
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Azotobacter agilis
-
-
-
1.8.1.4 Azotobacter vinelandii
-
-
-
1.8.1.4 Bacillus subtilis
-
-
-
1.8.1.4 Bos taurus
-
-
-
1.8.1.4 Brassica oleracea
-
-
-
1.8.1.4 Enterococcus faecalis
-
-
-
1.8.1.4 Escherichia coli
-
-
-
1.8.1.4 Escherichia coli
-
K-12
-
1.8.1.4 Escherichia coli B / ATCC 11303
-
-
-
1.8.1.4 Escherichia coli Crookes
-
-
-
1.8.1.4 Escherichia coli M191-6
-
-
-
1.8.1.4 Globisporangium ultimum
-
-
-
1.8.1.4 Homo sapiens
-
-
-
1.8.1.4 Leuconostoc mesenteroides
-
-
-
1.8.1.4 Mycobacterium tuberculosis
-
-
-
1.8.1.4 Neurospora crassa
-
-
-
1.8.1.4 Parvimonas micra
-
-
-
1.8.1.4 Phytophthora erythroseptica
-
-
-
1.8.1.4 Pichia kudriavzevii
-
-
-
1.8.1.4 Proteus vulgaris
-
-
-
1.8.1.4 Pseudomonas fluorescens
-
-
-
1.8.1.4 Rattus norvegicus
-
-
-
1.8.1.4 Saccharomyces cerevisiae
-
-
-
1.8.1.4 Serratia marcescens
-
-
-
1.8.1.4 Spinacia oleracea
-
-
-
1.8.1.4 Squalus acanthias
-
-
-
1.8.1.4 Sus scrofa
-
-
-
1.8.1.7 Escherichia coli
-
review
-
1.8.1.7 Hemicentrotus pulcherrimus
-
sea urchin, review
-
1.8.1.7 Homo sapiens
-
-
-
1.8.1.7 Penicillium chrysogenum
-
review
-
1.8.1.7 Rattus norvegicus
-
review
-
1.8.1.7 Saccharomyces cerevisiae
-
-
-
1.8.1.9 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.1.9 thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ catalytic mechanism Escherichia coli

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.4 brain
-
Sus scrofa
-
1.8.1.4 flower
-
Brassica oleracea
-
1.8.1.4 heart
-
Sus scrofa
-
1.8.1.4 heart
-
Bos taurus
-
1.8.1.4 kidney
-
Bos taurus
-
1.8.1.4 leaf
-
Spinacia oleracea
-
1.8.1.4 liver
-
Homo sapiens
-
1.8.1.4 liver
-
Rattus norvegicus
-
1.8.1.4 liver
-
Bos taurus
-
1.8.1.4 liver
-
Squalus acanthias
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.4 dihydrolipoamide + NAD+
-
Bacillus subtilis lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Escherichia coli lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Homo sapiens lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Rattus norvegicus lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Sus scrofa lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Saccharomyces cerevisiae lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Bos taurus lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Neurospora crassa lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Spinacia oleracea lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Pseudomonas fluorescens lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Serratia marcescens lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Enterococcus faecalis lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Proteus vulgaris lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Pichia kudriavzevii lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Leuconostoc mesenteroides lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Mycobacterium tuberculosis lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Azotobacter vinelandii lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Squalus acanthias lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Brassica oleracea lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Azotobacter agilis lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Parvimonas micra lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Globisporangium ultimum lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Phytophthora erythroseptica lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Escherichia coli B / ATCC 11303 lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Escherichia coli Crookes lipoamide + NADH
-
?
1.8.1.4 dihydrolipoamide + NAD+
-
Escherichia coli M191-6 lipoamide + NADH
-
?
1.8.1.7 GSSG + NADPH
-
Homo sapiens glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH
-
Homo sapiens glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH
-
Saccharomyces cerevisiae glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH
-
Hemicentrotus pulcherrimus glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Rattus norvegicus glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Rattus norvegicus glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Saccharomyces cerevisiae glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Saccharomyces cerevisiae glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Penicillium chrysogenum glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Penicillium chrysogenum glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Hemicentrotus pulcherrimus glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 Escherichia coli glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 Rattus norvegicus glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 Rattus norvegicus glutathione + NADP+
-
ir
1.8.1.7 GSSG + NADPH production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 Penicillium chrysogenum glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli B / ATCC 11303 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli B / ATCC 11303 glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 Escherichia coli B / ATCC 11303 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli Crookes glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli Crookes glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 Escherichia coli Crookes glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli M191-6 glutathione + NADP+
-
?
1.8.1.7 GSSG + NADPH glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine Escherichia coli M191-6 glutathione + NADP+
-
r
1.8.1.7 GSSG + NADPH production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2 Escherichia coli M191-6 glutathione + NADP+
-
?
1.8.1.9 additional information reduction of thioredoxin by NADPH is virtually complete, equilibrium constant is 48 at pH 7 Escherichia coli ?
-
?
1.8.1.9 additional information reduction of thioredoxin by NADPH is virtually complete, equilibrium constant is 48 at pH 7 Escherichia coli B / ATCC 11303 ?
-
?
1.8.1.9 additional information reduction of thioredoxin by NADPH is virtually complete, equilibrium constant is 48 at pH 7 Escherichia coli Crookes ?
-
?
1.8.1.9 additional information reduction of thioredoxin by NADPH is virtually complete, equilibrium constant is 48 at pH 7 Escherichia coli M191-6 ?
-
?
1.8.1.9 thioredoxin + NADP+ wide variety of electron acceptors Escherichia coli thioredoxin disulfide + NADPH
-
?
1.8.1.9 thioredoxin + NADP+ metabolic function of thioredoxin reductase-thioredoxin system: supplies reducing equivalents for a wide variety of acceptors, e.g. : ribonucleotide reductase, nonspecific protein disulfide reductase, methionine sulfoxide reductase, D-proline reductase Escherichia coli thioredoxin disulfide + NADPH
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.1.7 25
-
assay at Escherichia coli
1.8.1.7 25
-
assay at Homo sapiens
1.8.1.7 25
-
assay at Saccharomyces cerevisiae
1.8.1.7 25
-
assay at Hemicentrotus pulcherrimus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.1.7 48.3
-
glutathione disulfide reoxidation Homo sapiens
1.8.1.9 additional information
-
additional information
-
Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.1.7 6.8
-
broad optimum Homo sapiens
1.8.1.7 7
-
NADPH + GSSG Rattus norvegicus
1.8.1.7 7
-
NADPH + GSSG Saccharomyces cerevisiae
1.8.1.7 8
-
glutathione disulfide oxidation Saccharomyces cerevisiae
1.8.1.9 7.7
-
about Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.4 NAD+
-
Bacillus subtilis
1.8.1.4 NAD+
-
Escherichia coli
1.8.1.4 NAD+
-
Homo sapiens
1.8.1.4 NAD+
-
Rattus norvegicus
1.8.1.4 NAD+
-
Sus scrofa
1.8.1.4 NAD+
-
Saccharomyces cerevisiae
1.8.1.4 NAD+
-
Bos taurus
1.8.1.4 NAD+
-
Neurospora crassa
1.8.1.4 NAD+
-
Spinacia oleracea
1.8.1.4 NAD+
-
Pseudomonas fluorescens
1.8.1.4 NAD+
-
Serratia marcescens
1.8.1.4 NAD+
-
Enterococcus faecalis
1.8.1.4 NAD+
-
Proteus vulgaris
1.8.1.4 NAD+
-
Pichia kudriavzevii
1.8.1.4 NAD+
-
Leuconostoc mesenteroides
1.8.1.4 NAD+
-
Mycobacterium tuberculosis
1.8.1.4 NAD+
-
Azotobacter vinelandii
1.8.1.4 NAD+
-
Squalus acanthias
1.8.1.4 NAD+
-
Brassica oleracea
1.8.1.4 NAD+
-
Azotobacter agilis
1.8.1.4 NAD+
-
Parvimonas micra
1.8.1.4 NAD+
-
Globisporangium ultimum
1.8.1.4 NAD+
-
Phytophthora erythroseptica
1.8.1.7 FAD
-
Homo sapiens
1.8.1.7 FAD
-
Rattus norvegicus
1.8.1.7 FAD
-
Penicillium chrysogenum
1.8.1.7 FAD
-
Hemicentrotus pulcherrimus
1.8.1.7 FAD 5 thiol groups per FAD Escherichia coli
1.8.1.7 FAD 4 thiol groups per FAD Saccharomyces cerevisiae
1.8.1.7 NADPH
-
Escherichia coli
1.8.1.7 NADPH
-
Homo sapiens
1.8.1.7 NADPH
-
Rattus norvegicus
1.8.1.7 NADPH
-
Saccharomyces cerevisiae
1.8.1.7 NADPH
-
Penicillium chrysogenum
1.8.1.7 NADPH
-
Hemicentrotus pulcherrimus
1.8.1.9 FAD 2 FAD per dimer Escherichia coli
1.8.1.9 NADPH specific for Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.9 0.015
-
NADP+ at 25°C Escherichia coli