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Literature summary extracted from

  • Steenkamp, D.J.; Beinert, H.
    Mechanistic studies on the dehydrogenases of methylotrophic bacteria. 2. Kinetic studies on the intramolecular electron transfer in trimethylamine and dimethylamine dehydrogenase (1982), Biochem. J., 207, 241-252.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.8.2 trimethylamine hyperbolic substrate inhibition Hyphomicrobium sp.
1.5.8.2 trimethylamine hyperbolic substrate inhibition Methylophilus methylotrophus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.5.8.1 Iron contains a [4Fe-4S]cluster that provides an output of single electrons to a flavoprotein which functions as a one-electron acceptor Hyphomicrobium sp.
1.5.8.2 Fe 4Fe-4S-center Methylophilus methylotrophus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein Methylophilus methylotrophus transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein Hyphomicrobium sp. transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein Methylophilus methylotrophus W3A1 transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein Hyphomicrobium sp. X transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.5.8.1 Hyphomicrobium sp.
-
X
-
1.5.8.1 Hyphomicrobium sp. X
-
X
-
1.5.8.2 Hyphomicrobium sp.
-
Hyphomicrobium X
-
1.5.8.2 Methylophilus methylotrophus
-
-
-
1.5.8.2 Methylophilus methylotrophus W3A1
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.8.2
-
Methylophilus methylotrophus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.8.2 cell culture
-
Methylophilus methylotrophus
-
1.5.8.2 cell culture
-
Hyphomicrobium sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster Methylophilus methylotrophus dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster Hyphomicrobium sp. dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster Methylophilus methylotrophus W3A1 dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?
1.5.8.2 trimethylamine + H2O + electron transferring flavoprotein transfer of electrons to electron acceptors is mediated through the 4Fe-4S cluster Hyphomicrobium sp. X dimethylamine + formaldehyde + reduced electron transferring flavoprotein
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.8.1 6-S-cysteinyl-FMN the flavin component accepts two electrons from the substrate Hyphomicrobium sp.
1.5.8.2 electron transferring flavoprotein
-
Methylophilus methylotrophus
1.5.8.2 electron transferring flavoprotein
-
Hyphomicrobium sp.
1.5.8.2 FMN
-
Methylophilus methylotrophus