EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.1.88 | medicine | attractive target for antibacterial drug discovery | Bacillus subtilis |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.1.88 | Def and YkrB, expression in Escherichia coli | Bacillus subtilis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.88 | actinonin | 50% inhibition of enzyme Def at 95 nM, 50% inhibition of enzyme form YkrB by 130 nM | Bacillus subtilis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.88 | 2.3 | - |
N-formyl-Met-Ala-Ser | enzyme YkrB | Bacillus subtilis | |
3.5.1.88 | 3 | - |
N-formyl-Met-Ala-Ser | enzyme Def | Bacillus subtilis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.88 | Bacillus subtilis | - |
harbours two functional peptide deformylase: Def and YkrB. YkrB probably is the predominant deformylase | - |
3.5.1.88 | Pseudomonas aeruginosa | - |
two functional deformylases | - |
3.5.1.88 | Streptococcus pneumoniae | - |
two functional deformylases | - |
3.5.1.88 | Streptococcus pyogenes | - |
two functional deformylases | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.1.88 | Def and YkrB, recombinant enzyme | Bacillus subtilis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.88 | N-formyl-Met-Ala-Ser + H2O | - |
Bacillus subtilis | formate + Met-Ala-Ser | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.88 | 0.07 | - |
N-formyl-Met-Ala-Ser | enzyme Def | Bacillus subtilis | |
3.5.1.88 | 0.17 | - |
N-formyl-Met-Ala-Ser | enzyme YkrB | Bacillus subtilis |