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Literature summary extracted from

  • Ackerman, S.K.; Douglas, S.D.
    N-Formyl-L-methionine deformylase activity in human leucocytes and platelets (1979), Biochem. J., 182, 885-887.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.31 1,10-phenanthroline 2 mM, 90-100% inhibition Homo sapiens
3.5.1.31 dithiothreitol 2 mM, 90-100% inhibition Homo sapiens
3.5.1.31 EDTA 2 mM, 65-80% inhibition Homo sapiens
3.5.1.31 phenylmethanesulfonyl fluoride 2 mM, 10% inhibition Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.31 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.31 Co2+ 0.1 mM, 7-10fold stimulation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.31 additional information Homo sapiens the enzyme may be important in modulation of neutrophil responses to chemoattractant formylmethionyl peptides or similar compounds ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.31 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.31 leukocyte
-
 Homo sapiens
-
3.5.1.31 platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.31 additional information the enzyme may be important in modulation of neutrophil responses to chemoattractant formylmethionyl peptides or similar compounds Homo sapiens ?
-
 ?
3.5.1.31 N-formyl-L-methionine + H2O
-
 Homo sapiens formate + L-methionine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.31 additional information
-
 activity in 0.1 M Tris buffer is 10fold lower than in 0.1 M phosphate buffer, pH 8.5 Homo sapiens
3.5.1.31 7.5
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.1.31 6.5 9.5 pH 6.5: about 75% of maximal activity, pH 9.5: about 50% of maximal activity Homo sapiens