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Literature summary extracted from

  • Stirling, J.L.
    Separation and characterization of N-acetyl-beta-glucosaminidases A and P from maternal serum (1972), Biochim. Biophys. Acta, 271, 154-162.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.52 acetate 80% inhibition with 66 mM Homo sapiens
3.2.1.52 N-acetyl-D-galactosamine 60% inhibition with 1 mM Homo sapiens
3.2.1.52 p-chloromercuribenzoate form A: 93% inhibition with 0.1 mM, form P: 98% inhibition with 0.1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.52 0.55
-
 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside form P Homo sapiens
3.2.1.52 0.65
-
 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside form A Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.52 140000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.52 N-acetyl-beta-D-hexosaminides + H2O Homo sapiens
-
 N-acetyl-D-hexosamines
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.52 Homo sapiens
-
 pregnant women
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.52 amniotic fluid
-
 Homo sapiens
-
3.2.1.52 fetus fetal membrane Homo sapiens
-
3.2.1.52 placenta
-
 Homo sapiens
-
3.2.1.52 serum cord serum and maternal serum Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.52 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.52 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside + H2O
-
 Homo sapiens 4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranoside
-
 ?
3.2.1.52 N-acetyl-beta-D-hexosaminides + H2O
-
 Homo sapiens N-acetyl-D-hexosamines
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.2.1.52 37
-
 at pH 3.0, form P: loss of 3% of activity after 30 min, form A: loss of 22% of activity after 30 min Homo sapiens
3.2.1.52 50
-
 at pH 5.0, form P: almost stable for 40 min, form A: loss of 70% of activity during 40 min Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.52 additional information
-
-
 Homo sapiens