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Literature summary extracted from

  • Den Tandt, W.R.; Scharpe, S.
    Characteristics of hexosaminidase A in homogenates of white blood cells using methylumbelliferyl-N-acetyl-beta-D-glucosaminide-6-sulphate as substrate (1991), Clin. Chim. Acta, 199, 231-236.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.52 taurocholate concentrations of 0.05 M and 0.1 M cause 140% and 160% of activity Homo sapiens

Application

EC Number Application Comment Organism
3.2.1.52 medicine diagosis of Tay-Sachs disease Homo sapiens

General Stability

EC Number General Stability Organism
3.2.1.52 resistant to mechanical inactivation by homogenization or freezing and thawing Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.52 Hg2+ with 0.75 M 6% of activity remains Homo sapiens
3.2.1.52 N-acetyl-D-galactosamine
-
Homo sapiens
3.2.1.52 N-acetyl-D-glucosamine with 0.75 M 34% of activity remains Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.52 1.8
-
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.52 lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.52 N-acetyl-beta-D-hexosaminides + H2O Homo sapiens
-
N-acetyl-D-hexosamines
-
?

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
3.2.1.52 dimethyl sulfoxide with 7.5% 14% of activity remains Homo sapiens
3.2.1.52 dimethylformamide with 7.5% 9% of activity remains Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.52 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.2.1.52 glycoprotein
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.52 granulocyte
-
Homo sapiens
-
3.2.1.52 leukocyte
-
Homo sapiens
-
3.2.1.52 mononuclear cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.52 0.0012 0.0025 substrate: 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.52 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate + H2O
-
Homo sapiens 4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate
-
?
3.2.1.52 N-acetyl-beta-D-hexosaminides + H2O
-
Homo sapiens N-acetyl-D-hexosamines
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.2.1.52
-
37 stable up to 24 h Homo sapiens
3.2.1.52 50
-
rapid inactivation, retarded by acidification Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.52 3.5 4 substrate: 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate Homo sapiens