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Literature summary extracted from

  • Rueffer, M.
    New reactions in the protoberberine biosynthetic pathway (1993), Chem. Listy, 87, 215-217.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.68 CO inhibition can be partly reverted by blue light Berberidaceae
1.14.19.68 CO inhibition can be partly reverted by blue light Ranunculaceae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 Berberidaceae reaction in protoberberine biosynthetic pathway (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 Ranunculaceae reaction in protoberberine biosynthetic pathway (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.68 Berberidaceae
-
-
-
1.14.19.68 Ranunculaceae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2
-
 Berberidaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2
-
 Ranunculaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 reaction in protoberberine biosynthetic pathway Berberidaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 reaction in protoberberine biosynthetic pathway Ranunculaceae (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 23% of the activity compared to NADPH Berberidaceae ?
-
 ?
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 23% of the activity compared to NADPH Ranunculaceae ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.68 cytochrome P450 cytochrome P-450 enzyme Berberidaceae
1.14.19.68 cytochrome P450 cytochrome P-450 enzyme Ranunculaceae