EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.19.68 | cytochrome c | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | juglone | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | ketoconazole | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | menadione | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | Metyrapone | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | Plumbagin | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | Prochloraz | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | Propiconazole | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | Tetcyclacis | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | Triadimefone | microsomal-bound enzyme | Thalictrum tuberosum | |
1.14.19.68 | tropolone | microsomal-bound enzyme | Thalictrum tuberosum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.19.68 | 0.0115 | - |
(S)-tetrahydrocolumbamine | canadine synthase in complex with a cytochrome P-450 reductase | Thalictrum tuberosum | |
1.14.19.68 | 0.033 | - |
[reduced NADPH-hemoprotein reductase] | canadine synthase in complex with a cytochrome P-450 reductase | Thalictrum tuberosum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.19.68 | microsome | - |
Thalictrum tuberosum | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.19.68 | (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 | Thalictrum tuberosum | penultimate step in the biosynthesis of the protoberberine alkaloid, berberine | (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O | (S)-canadine is identical with (S)-tetrahydroberberine | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.19.68 | Berberis aristata | - |
- |
- |
1.14.19.68 | Berberis crataegina | - |
- |
- |
1.14.19.68 | Berberis henryana | - |
- |
- |
1.14.19.68 | Berberis stolonifera | - |
- |
- |
1.14.19.68 | Berberis taliensis | - |
- |
- |
1.14.19.68 | Coptis japonica | - |
- |
- |
1.14.19.68 | Thalictrum glabrum | - |
- |
- |
1.14.19.68 | Thalictrum glaucum | - |
- |
- |
1.14.19.68 | Thalictrum macrocarpum | - |
- |
- |
1.14.19.68 | Thalictrum tuberosum | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.19.68 | cell culture | - |
Coptis japonica | - |
1.14.19.68 | cell culture | protoberberine producing cell line | Thalictrum tuberosum | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.19.68 | (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 | high substrate specificity | Thalictrum tuberosum | (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O | (S)-canadine is identical with (S)-tetrahydroberberine | ? | |
1.14.19.68 | (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 | penultimate step in the biosynthesis of the protoberberine alkaloid, berberine | Thalictrum tuberosum | (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O | (S)-canadine is identical with (S)-tetrahydroberberine | ? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.19.68 | 40 | - |
canadine synthase in complex with a cytochrome P-450 reductase | Thalictrum tuberosum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.19.68 | 8.5 | - |
canadine synthase in complex with a cytochrome P-450 reductase | Thalictrum tuberosum |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.19.68 | cytochrome P450 | the enzyme forms a complex with a cytochrome P-450 reductase | Thalictrum tuberosum |