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Literature summary extracted from

  • Vanhaesebroeck, B.; Leevers, S.J.; Panayotou, G.; Waterfield, M.D.
    Phosphoinositide 3-kinases: a conserved family of signal transducers (1997), Trends Biochem. Sci., 22, 267-272.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.153 additional information Mammalia the adaptor subunits of the class IA enzymes bind phosphorylated Tyr residues, thereby linking the phosphoinositide 3-kinases catalytic subunit to tyr kinase signalling pathways ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.153 Mammalia
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
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 Mammalia ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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 ?
2.7.1.153 ATP + phosphatidylinositol
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 Mammalia ADP + phosphatidylinositol 3-phosphate
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 ?
2.7.1.153 ATP + phosphatidylinositol 4-phosphate
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 Mammalia ADP + phosphatidylinositol 4,5-diphosphate
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 ?
2.7.1.153 additional information enzyme interacts with active, GTP-bound Ras Mammalia ?
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 ?
2.7.1.153 additional information the adaptor subunits of the class IA enzymes bind phosphorylated Tyr residues, thereby linking the phosphoinositide 3-kinases catalytic subunit to tyr kinase signalling pathways Mammalia ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.153 More
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 Mammalia