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Literature summary extracted from

  • Kryukov, G.V.; Kumar, R.A.; Koc, A.; Sun, Z.; Gladyshev, V.N.
    Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase (2002), Proc. Natl. Acad. Sci. USA, 99, 4245-4250.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.12 gene selR, DNA and amino acid sequence determination and analysis, expression as His-tagged enzyme in Escherichia coli strain BL21(DE3) Drosophila melanogaster
1.8.4.12 overexpression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3) Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.4.12 selenium selenoprotein Mus musculus
1.8.4.12 selenium selenoprotein Drosophila melanogaster
1.8.4.12 Zn2+ metalloenzyme, content determination Mus musculus
1.8.4.12 Zn2+ metalloenzyme, content determination Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin Mus musculus MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin Drosophila melanogaster MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 additional information Mus musculus enzyme provides protection for the cell against oxidative stress ?
-
 ?
1.8.4.12 additional information Drosophila melanogaster enzyme provides protection for the cell against oxidative stress ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Drosophila melanogaster Q8INK9
-
-
1.8.4.12 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.12 recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) Drosophila melanogaster
1.8.4.12 recombinant wild-type and mutant enzymes from Escherichia coli strain BL21(DE3) by heparin affinity chromatography Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview Drosophila melanogaster L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form Drosophila melanogaster L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 additional information enzyme provides protection for the cell against oxidative stress Mus musculus ?
-
 ?
1.8.4.12 additional information enzyme provides protection for the cell against oxidative stress Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 methionine-R-sulfoxide reductase
-
 Mus musculus
1.8.4.12 methionine-R-sulfoxide reductase
-
 Drosophila melanogaster
1.8.4.12 selenoprotein R
-
 Mus musculus
1.8.4.12 selenoprotein R
-
 Drosophila melanogaster
1.8.4.12 SelR
-
 Mus musculus
1.8.4.12 SelR
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.12 thioredoxin
-
 Mus musculus
1.8.4.12 thioredoxin
-
 Drosophila melanogaster