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Literature summary extracted from

  • Seo, B.B.; Kitajima-Ihara, T.; Chan, E.K.L.; Scheffler, I.E.; Matsuno-Yagi, A.; Yagi, T.
    Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells (1998), Proc. Natl. Acad. Sci. USA, 95, 9167-9171.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.1.1.2 medicine the NDI1 gene provides a potentially useful tool for gene therapy of mitochondrial diseases caused by complex I deficiency Saccharomyces cerevisiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.1.2 the NDI1 gene encoding the rotenone-insensitive internal NADH-quinone oxidoreductase is cotransfected into complex-I-deficient Chinese hamster CCL16-B2 cells. The enzyme is expressed functionally and catalyzes electron transfer from NADH in the matrix to ubiquinone 10 in the inner mitochonbdrial membranes Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 rotenone rotenone-insensitive enzyme Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Saccharomyces cerevisiae
-
 rotenone-insensitive enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone
-
 Saccharomyces cerevisiae NAD+ + ubiquinol
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Saccharomyces cerevisiae