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Literature summary extracted from

  • Pfenninger-Li, X.D.; Albracht, S.P.J.; van Belzen, R.; Dimroth, P.
    NADH:ubiquinone oxidoreductase of Vibrio alginolyticus: Purification, properties, and reconstitution of the Na+ pump (1996), Biochemistry, 35, 6233-6242.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.1.1 NADH incubation of the aerobic enzyme with NADH in the absence of an electron acceptor, the enzyme is destroyed with a half-inactivation time of about 2 min Vibrio alginolyticus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.1.1 membrane
-
 Vibrio alginolyticus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.1.1 Iron an Fe-S-cluster of the [2Fe-2S] type is involved in electron translocation Vibrio alginolyticus
7.2.1.1 Na+ activates Vibrio alginolyticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.1.1 NADH + ubiquinone Vibrio alginolyticus the enzyme functions as a primary Na+ pump ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.1.1 Vibrio alginolyticus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.1.1
-
 Vibrio alginolyticus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.2.1.1 additional information
-
-
 Vibrio alginolyticus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.1.1 NADH + 2-methylnaphthoquinone
-
 Vibrio alginolyticus NAD+ + 2-methylnaphthalene-1,4-diol
-
 ?
7.2.1.1 NADH + ubiquinone
-
 Vibrio alginolyticus NAD+ + ubiquinol
-
 ?
7.2.1.1 NADH + ubiquinone the enzyme functions as a primary Na+ pump Vibrio alginolyticus ?
-
 ?
7.2.1.1 NADH + ubiquinone-1 electron transfer to ubiquinone-1 involves the semiquinone radical as an intermediate Vibrio alginolyticus NAD+ + ubiquinol-1
-
 ?

Subunits

EC Number Subunits Comment Organism
7.2.1.1 More the enzyme consists of three different hydrophilic and probably three different hydrophobic subunits Vibrio alginolyticus

Cofactor

EC Number Cofactor Comment Organism Structure
7.2.1.1 FAD enzyme contains FAD Vibrio alginolyticus
7.2.1.1 NADH
-
 Vibrio alginolyticus