Literature summary extracted from

Phelps, D.C.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: active site modification by 5-[p-(fluorosulfonyl)benzoyl]adenosine (1985), Biochemistry, 24, 3503-3507.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.6.1.2	5'-[p-(fluorosulfonyl)benzoyl]-adenosine	structural analog of adenosine, 2 mM, almost complete inactivation after 25 min, acetylpyridine adenine dinucleotide, NADP+, 5'-AMP, 5'-ADP or a mixture of 2'-AMP and 3'-AMP protect from inactivation, NADPH accelerates the inhibition rate, inhibition rate constant increases 50fold by increasing the pH from 6.0 to 8.5	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.6.1.2	mitochondrial membrane	-	Bos taurus	31966	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.1.2	Bos taurus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.6.1.2	heart	-	Bos taurus	-

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.6.1.2	additional information	no flavin cofactor, differentiation from EC 1.6.1.1.	Bos taurus
1.6.1.2	NAD+	-	Bos taurus
1.6.1.2	NADH	-	Bos taurus
1.6.1.2	NADP+	-	Bos taurus
1.6.1.2	NADPH	-	Bos taurus

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Release 2023.1 (January 2023)