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Literature summary extracted from

  • Phelps, D.C.; Hatefi, Y.
    Mitochondrial nicotinamide nucleotide transhydrogenase: nonidentical modification by N,N-dicyclohexylcarbodiimide and N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline at the NAD(H) binding site (1985), Arch. Biochem. Biophys., 243, 298-304.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.1.2 N,N'-Dicylclohexylcarbodiimide NADH, acetylpyridine adenine dinucleotide, 5'-AMP and 5'-ADP offer nearly complete protection Bos taurus
1.6.1.2 N-(Ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.1.2 2.6
-
 NMNH reduction of thio-NADP+ in energized submitochondrial particles Bos taurus
1.6.1.2 3.4
-
 NMNH reduction of thio-NADP+ in non energized submitochondrial particles Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.1.2 mitochondrial membrane
-
 Bos taurus 31966
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.1.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.1.2 NMNH + thio-NADP+
-
 Bos taurus NMN + thio-NADPH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.1.2 NAD+
-
 Bos taurus
1.6.1.2 NADH
-
 Bos taurus
1.6.1.2 NADP+
-
 Bos taurus
1.6.1.2 NADPH
-
 Bos taurus