Literature summary extracted from

Yamaguchi, M.; Hatefi, Y.
Mitochondrial nicotinamide nucleotide transhydrogenase: NADPH binding increases and NADP binding decreases the acidity and susceptibility to modification of cysteine-893 (1989), Biochemistry, 28, 6050-6056.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.6.1.2	methylmethane thiosulfonate	modification of Cys-893	Bos taurus
1.6.1.2	N-ethylmaleimide	at neutral pH NADP+ and 2'-AMP partially protect while NADPH accelerates the inactivation rate, little inactivation below pH 7.5, rapid inactivation above, modification of Cys-893 is responsible for inactivation	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.6.1.2	mitochondrial membrane	-	Bos taurus	31966	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.1.2	Bos taurus	-	-	-

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.6.1.2	NAD+	-	Bos taurus
1.6.1.2	NADH	-	Bos taurus
1.6.1.2	NADP+	-	Bos taurus
1.6.1.2	NADPH	-	Bos taurus

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Release 2023.1 (January 2023)