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Literature summary extracted from

  • Jackson, J.B.; Lever, T.M.; Rydström, J.; Persson, B.; Carlenor, E.
    Proton-translocating transhydrogenase from photosynthetic bacteria (1991), Biochem. Soc. Trans., 19, 573-575.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.1 carbonylcyanide-4-trifluoromethoxyphenyl hydrazone 0.002 mM stimulates the rate of the forward reaction by 8fold and of the reverse reaction by 10fold Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.1 valinomycin
-
 Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.1.2 chromatophore
-
 Mammalia
-
-
1.6.1.2 mitochondrial membrane
-
 Mammalia 31966
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.6.1.2 47000
-
 alpha2,beta2, 2 * 50000 + 2 * 47000 Escherichia coli
1.6.1.2 50000
-
 alpha2,beta2, 2 * 50000 + 2 * 47000 Escherichia coli
1.6.1.2 196000
-
-
 Mammalia
7.1.1.1 48000
-
 1 * 50000 + 1 * 48000, SDS-PAGE Escherichia coli
7.1.1.1 50000
-
 1 * 50000 + 1 * 48000, SDS-PAGE Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.1 NADPH + NAD+ + H+[side 1] Escherichia coli
-
 NADP+ + NADH + H+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.1.2 Escherichia coli
-
-
-
1.6.1.2 Mammalia
-
-
-
7.1.1.1 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.1.1.1 DEAE-Sepharose column chromatography and hydroxyapatite column chromatography Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.1.2 NADH + NADP+
-
 Escherichia coli NAD+ + NADPH
-
 ?
1.6.1.2 NADH + NADP+ the reaction is coupled to a transmembrane proton translocation from cytosol to mitochondria Mammalia NAD+ + NADPH
-
 ?
7.1.1.1 NADPH + NAD+ + H+[side 1]
-
 Escherichia coli NADP+ + NADH + H+[side 2]
-
 ?
7.1.1.1 NADPH + oxidized acetylpyridine adenine dinucleotide + H+[side 1]
-
 Escherichia coli NADP+ + reduced acetylpyridine adenine dinucleotide + H+[side 2]
-
 ?
7.1.1.1 thio-NADPH + NAD+ + H+[side 1]
-
 Escherichia coli thio-NADP+ + NADH + H+[side 2]
-
 ?

Subunits

EC Number Subunits Comment Organism
1.6.1.2 dimer
-
 Mammalia
1.6.1.2 tetramer alpha2,beta2, 2 * 50000 + 2 * 47000 Escherichia coli
7.1.1.1 heterodimer 1 * 50000 + 1 * 48000, SDS-PAGE Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
7.1.1.1 H+-thase
-
 Escherichia coli
7.1.1.1 nicotinamide adenine dinucleotide H +-transhydrogenase
-
 Escherichia coli
7.1.1.1 proton-translocating transhydrogenase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.1.2 NAD+
-
 Mammalia
1.6.1.2 NAD+
-
 Escherichia coli
1.6.1.2 NADH
-
 Mammalia
1.6.1.2 NADH
-
 Escherichia coli
1.6.1.2 NADP+
-
 Mammalia
1.6.1.2 NADP+
-
 Escherichia coli
1.6.1.2 NADPH
-
 Mammalia
1.6.1.2 NADPH
-
 Escherichia coli