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Literature summary extracted from

  • Blemings, K.P.; Crenshaw, T.D.; Swick, R.W.; Benevenga, N.J.
    Lysine-alpha-ketoglutarate reductase and saccharopine dehydrogenase are located only in the mitochondrial matrix in rat liver (1994), J. Nutr., 124, 1215-1221.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.5.1.8 Triton X-100 is necessary to observe maximal enzyme activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.8 additional information not inhibited by Triton X-100 up to 2.5 ml/l Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.8 mitochondrial matrix enzyme found only in the mitochondrial matrix Rattus norvegicus 5759
-
1.5.1.8 additional information not found in peroxisomes or lysosomes Rattus norvegicus
-
-
1.5.1.9 mitochondrion mitochondrial matrix Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Rattus norvegicus initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Rattus norvegicus involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.8 Rattus norvegicus
-
 male sprague-dawley rats
-
1.5.1.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.8 liver
-
 Rattus norvegicus
-
1.5.1.9 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Rattus norvegicus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.9 SacD
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.8 NADPH
-
 Rattus norvegicus