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Literature summary extracted from

  • Blakley, R.L.; McDougall, B.M.
    Dihydrofolic reductase from Streptococcus faecalis R (1961), J. Biol. Chem., 236, 1163-1167.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 aminopterin
-
 Enterococcus faecalis
1.5.1.3 folate
-
 Enterococcus faecalis
1.5.1.3 methotrexate i.e. N10-methylpteroylglutamic acid Enterococcus faecalis
1.5.1.3 p-chloromercuribenzoate
-
 Enterococcus faecalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.3 additional information
-
 additional information
-
 Enterococcus faecalis
1.5.1.3 0.004
-
 7,8-dihydrofolate
-
 Enterococcus faecalis

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Enterococcus faecalis
-
-
-
1.5.1.3 Enterococcus faecalis R / ATCC 8043
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.3 partial Enterococcus faecalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH
-
 Enterococcus faecalis 5,6,7,8-tetrahydrofolate + NADP+
-
 ir
1.5.1.3 7,8-dihydrofolate + NADPH
-
 Enterococcus faecalis R / ATCC 8043 5,6,7,8-tetrahydrofolate + NADP+
-
 ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.3 6.7
-
-
 Enterococcus faecalis
1.5.1.3 6.8
-
-
 Enterococcus faecalis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.5.1.3 5.3 8 half-maximal activities at pH 5.3 and pH 8.0 Enterococcus faecalis

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADH not Enterococcus faecalis
1.5.1.3 NADPH
-
 Enterococcus faecalis