EC Number | General Stability | Organism |
---|---|---|
1.5.1.20 | extremely sensitive to proteolysis | Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.20 | dihydrofolate | - |
Sus scrofa | |
1.5.1.20 | dihydropteroylhexaglutamate | - |
Sus scrofa | |
1.5.1.20 | dihydropteroylpolyglutamate | most potent inhibitor is dihydropteroylhexaglutamate | Sus scrofa | |
1.5.1.20 | S-adenosylmethionine | inhibition partially reversed by S-adenosylhomocysteine | Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.20 | 0.016 | - |
NADPH | 5,10-methylenetetrahydrofolate reductase reaction, pH 7.2 | Sus scrofa | |
1.5.1.20 | 0.019 | - |
5,10-methylenetetrahydrofolate | methylenetetrahydrofolate reductase reaction, pH 6.7 | Sus scrofa | |
1.5.1.20 | 0.088 | - |
5,10-methylenetetrahydrofolate | methylenetetrahydrofolate reductase reaction, pH 7.2 | Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.5.1.20 | 77300 | - |
SDS-PAGE | Sus scrofa |
1.5.1.20 | 136000 | - |
scanning transmission electron microscopy | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.20 | 5,10-methylenetetrahydrofolate + NADPH | Sus scrofa | initial enzyme in pathway leading to synthesis of S-adenosylmethionine | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.20 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.5.1.20 | homogeneity | Sus scrofa |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ | mechanism | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.20 | liver | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.5.1.20 | additional information | - |
different assay methods | Sus scrofa |
1.5.1.20 | 19.4 | - |
- |
Sus scrofa |
EC Number | Storage Stability | Organism |
---|---|---|
1.5.1.20 | -70°C, 10% glycerol, several months | Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.20 | 1-pyrroline-5-carboxylate + NADH + H+ | - |
Sus scrofa | L-proline + NAD+ | - |
r | |
1.5.1.20 | 5,10-methylenetetrahydrofolate + NADPH | ping pong kinetics | Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? | |
1.5.1.20 | 5,10-methylenetetrahydrofolate + NADPH | enzyme also catalyzes the NADPH-linked reduction of quinoid dihydrofolate and dihydropterin derivates | Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? | |
1.5.1.20 | 5,10-methylenetetrahydrofolate + NADPH | initial enzyme in pathway leading to synthesis of S-adenosylmethionine | Sus scrofa | ? | - |
? | |
1.5.1.20 | 5-methyltetrahydrofolate + oxidized menadione | ping pong kinetics | Sus scrofa | 5,10-methylenetetrahydrofolate + reduced menadione | - |
? | |
1.5.1.20 | NADPH + H+ + menadione | ping pong kinetics | Sus scrofa | NADP+ + menadiol | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.5.1.20 | dimer | dimer or trimer, 2 or 3 * 77300, SDS-PAGE | Sus scrofa |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.20 | 160 | - |
NADH | - |
Sus scrofa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.20 | FAD | flavoprotein | Sus scrofa | |
1.5.1.20 | FAD | each subunit contains noncovalently bound FAD | Sus scrofa |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.20 | 0.000013 | - |
dihydropteroylhexaglutamate | - |
Sus scrofa |