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Literature summary extracted from
- Methylenetetrahydrofolate reductase. Steady state and rapid reaction studies on the NADPH-methylenetetrahydrofolate, NADPH-menadione, and methyltetrahydrofolate-menadione oxidoreductase activities of the enzyme (1983), J. Biol. Chem., 258, 11510-11514.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.5.1.20 | 0.028 | - |
NADPH | NADPH-menadione oxidoreductase reaction | Sus scrofa |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.1.20 | 5,10-methylenetetrahydrofolate + NADPH | Sus scrofa | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.1.20 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.5.1.20 | homogeneity | Sus scrofa |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.5.1.20 | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ | mechanism | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.5.1.20 | liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.1.20 | (6R,S)-5,10-methylenetetrahydrofolate + ? | - |
Sus scrofa | ? | - |
? | |
| 1.5.1.20 | 5,10-methylenetetrahydrofolate + NADPH | ping pong bi bi mechanism | Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? | |
| 1.5.1.20 | 5,10-methylenetetrahydrofolate + NADPH | - |
Sus scrofa | ? | - |
? | |
| 1.5.1.20 | 5-methyltetrahydrofolate + oxidized menadione | - |
Sus scrofa | 5,10-methylenetetrahydrofolate + reduced menadione | - |
? | |
| 1.5.1.20 | NADPH + H+ + menadione | - |
Sus scrofa | NADP+ + menadiol | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.5.1.20 | 50 | - |
methylenetetrahydrofolate | - |
Sus scrofa | |
| 1.5.1.20 | 160 | - |
NADPH | - |
Sus scrofa | |
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