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Literature summary extracted from

  • Strecker, H.J.
    DELTA1-pyrroline-5-carboxylate reductase (calf liver) (reduction of DELTA1-pyrroline-5-carboxylate to proline) (1971), Methods Enzymol., 17B, 258-261.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.2 ADP
-
 Bos taurus
1.5.1.2 Ag+
-
 Bos taurus
1.5.1.2 ATP
-
 Bos taurus
1.5.1.2 Cd2+ 90% inhibition at 3.3 mM Bos taurus
1.5.1.2 Cu2+ 90% inhibition at 3.3 mM Bos taurus
1.5.1.2 Hg2+
-
 Bos taurus
1.5.1.2 hydroxylamine
-
 Bos taurus
1.5.1.2 Mn2+
-
 Bos taurus
1.5.1.2 NAD+
-
 Bos taurus
1.5.1.2 proline
-
 Bos taurus
1.5.1.2 thiazolidine-4-carboxylic acid
-
 Bos taurus
1.5.1.2 Zn2+
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.2 additional information
-
 additional information
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.2 Bos taurus
-
 calf
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.2 7.1
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Bos taurus L-proline + NAD(P)+
-
 ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.2 6.7 7.4
-
 Bos taurus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.5.1.2 6
-
 irreversible inactivation below Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.2 NADH preferentially Bos taurus
1.5.1.2 NADPH
-
 Bos taurus