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Literature summary extracted from

  • Mejia, N.; Mackenzie, R.E.
    NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells (1985), J. Biol. Chem., 260, 14616-14620.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.5.1.15 medicine enzyme distribution suggests it can be useful as an oncodevelopmental marker Mus musculus
1.5.1.15 medicine enzyme distribution suggests it can be useful as an oncodevelopmental marker Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH Cricetulus griseus
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH Mus musculus
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH Homo sapiens
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH Rattus norvegicus
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH Mesocricetus auratus
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH Cricetus cricetus
-
L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+ Cricetulus griseus
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+ Mus musculus
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+ Homo sapiens
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+ Rattus norvegicus
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+ Mesocricetus auratus
-
5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+ Cricetus cricetus
-
5,10-methenyl-tetrahydrofolate + NADH
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.15 Cricetulus griseus
-
chinese hamster, ovary lines TR-3 and LR-73, 3T3and 3T3-SV40
-
1.5.1.15 Cricetus cricetus
-
black bellied hamster, cell line HA-Py(T), a polyoma virus-transformed hamster embryo fibroblast
-
1.5.1.15 Homo sapiens
-
human
-
1.5.1.15 Homo sapiens
-
normal human fibroblasts MCH-39, EBV-transformed normal human lymphoblast lines TL3 and TL4, human tumor lines MNNG/HOS(TE85 clone F-5), MCF-7, CCRF-CEM, osteosarcoma MG-63(ATCC CRL 1427), human chronic myeolitic leukemia line K562, Burkitt lymphoma line Raji, human choriocarcinoma BeWo, human intestinal carcinoma HCT
-
1.5.1.15 Mesocricetus auratus
-
Syrian hamster
-
1.5.1.15 Mus musculus
-
C57 black mice, murine ascites tumor lines, T-cell lymphoma EL4, Moloney virus-induced lymphoma YAC, mouse melanoma M4(original designation RPMI 7272), 3T3-SV40
-
1.5.1.15 Mus musculus
-
mouse, Ehrlich ascites tumor cells
-
1.5.1.15 Mus musculus
-
Ehrlich ascites line Swiss mice
-
1.5.1.15 Mus musculus
-
DBA mice, mastocyma P815 (ATCC TIB 64)
-
1.5.1.15 Mus musculus
-
cell lines YAC, P815
-
1.5.1.15 Rattus norvegicus
-
rat, Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.15 blood
-
Homo sapiens
-
1.5.1.15 bone marrow
-
Mus musculus
-
1.5.1.15 bone marrow
-
Rattus norvegicus
-
1.5.1.15 embryo
-
Mus musculus
-
1.5.1.15 embryo
-
Mesocricetus auratus
-
1.5.1.15 embryo
-
Cricetus cricetus
-
1.5.1.15 fetus
-
Homo sapiens
-
1.5.1.15 fetus
-
Rattus norvegicus
-
1.5.1.15 fibroblast
-
Mus musculus
-
1.5.1.15 fibroblast
-
Homo sapiens
-
1.5.1.15 fibroblast embryo fibroblast Mesocricetus auratus
-
1.5.1.15 fibroblast embryo fibroblast Cricetus cricetus
-
1.5.1.15 granulocyte
-
Homo sapiens
-
1.5.1.15 leukocyte cell line 3T3, mouse embryo Mus musculus
-
1.5.1.15 leukocyte cell line TL3and TL4, EBV-transformed Homo sapiens
-
1.5.1.15 liver
-
Homo sapiens
-
1.5.1.15 liver embryonic liver Mus musculus
-
1.5.1.15 liver embryonic liver Rattus norvegicus
-
1.5.1.15 lymphoblast
-
Homo sapiens
-
1.5.1.15 lymphocyte
-
Homo sapiens
-
1.5.1.15 ovary
-
Cricetulus griseus
-
1.5.1.15 spleen
-
Mus musculus
-
1.5.1.15 spleen
-
Rattus norvegicus
-
1.5.1.15 thymus
-
Mus musculus
-
1.5.1.15 thymus
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.15 0.0004
-
spleen Mus musculus
1.5.1.15 0.0007
-
thymus Mus musculus
1.5.1.15 0.00076
-
fibroblasts, syrian hamster embryo Mesocricetus auratus
1.5.1.15 0.0012
-
fetal rat Rattus norvegicus
1.5.1.15 0.0024
-
cell line M4, human cutaneous melanoma Homo sapiens
1.5.1.15 0.003
-
cell line LR-73, chinese hamster ovary Cricetulus griseus
1.5.1.15 0.0031
-
cell line K562, human chronic myeolcytic leukemia Homo sapiens
1.5.1.15 0.0033
-
cell line TL3, EBV-transformed Homo sapiens
1.5.1.15 0.0034
-
bone marrow Mus musculus
1.5.1.15 0.0039
-
cell line 3T3, mouse embryo Mus musculus
1.5.1.15 0.0042
-
hamster embryo fibroblast, Polyoma virus transformed Cricetus cricetus
1.5.1.15 0.0042
-
L-cells, Reovirus infected Mus musculus
1.5.1.15 0.0042
-
cell line HCT-8R, human intestinal carcinoma Homo sapiens
1.5.1.15 0.0046
-
cell line TL4, EBV-transformed Homo sapiens
1.5.1.15 0.0047
-
cell line MG-63, human osteosarcoma Homo sapiens
1.5.1.15 0.0049
-
cell line BeWo, human choriocarcinoma Homo sapiens
1.5.1.15 0.005
-
cell line TR-3, transformed Cricetulus griseus
1.5.1.15 0.005
-
cell line Raji, Burkitt lymphoma Homo sapiens
1.5.1.15 0.0055
-
cell line MNNG/HOS, human osteosarcoma Homo sapiens
1.5.1.15 0.0055
-
cell line P815, murine mastocytoma Mus musculus
1.5.1.15 0.0059
-
cell line P815, ascites in vivo Mus musculus
1.5.1.15 0.0066
-
cell line EL4, ascites in vivo Mus musculus
1.5.1.15 0.0068
-
L-cells, murine fibroblast Mus musculus
1.5.1.15 0.0069
-
cell line MCF-7, human breast carcinoma Homo sapiens
1.5.1.15 0.0078
-
cell line CCRF-CEM, human leukemia Homo sapiens
1.5.1.15 0.0089
-
Ehrlich ascites, ascites in vivo Mus musculus
1.5.1.15 0.0094
-
cell line EL4, murine T-cell lymphoma Mus musculus
1.5.1.15 0.0097
-
cell line YAC, murine lymphoma (Moloney virus-induced) Mus musculus
1.5.1.15 0.0105
-
cell line 3T3-SV40, SV40 transformed Mus musculus
1.5.1.15 0.02
-
Ehrlich ascites, murine mastocytoma Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH
-
Cricetulus griseus L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH
-
Mus musculus L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH
-
Homo sapiens L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH
-
Rattus norvegicus L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH
-
Mesocricetus auratus L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methenyl-tetrahydrofolate + NADH
-
Cricetus cricetus L-5,10-methylenetetrahydrofolate + NAD+
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+
-
Cricetulus griseus 5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+
-
Mus musculus 5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+
-
Homo sapiens 5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+
-
Rattus norvegicus 5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+
-
Mesocricetus auratus 5,10-methenyl-tetrahydrofolate + NADH
-
r
1.5.1.15 L-5,10-methylenetetrahydrofolate + NAD+
-
Cricetus cricetus 5,10-methenyl-tetrahydrofolate + NADH
-
r