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Literature summary extracted from

  • Strecker, H.J.
    The interconversion of glutamic acid and proline (1960), J. Biol. Chem., 235, 3218-3223.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.88 5-Aminopentanoate
-
 Bos taurus
1.2.1.88 ADP
-
 Bos taurus
1.2.1.88 AMP
-
 Bos taurus
1.2.1.88 ATP
-
 Bos taurus
1.2.1.88 CN-
-
 Bos taurus
1.2.1.88 Cu2+
-
 Bos taurus
1.2.1.88 additional information no inhibition: Ca2+, Mn2+, Mg2+, Ba2+, Pb2+, N-ethylmaleimide, o-phenanthroline Bos taurus
1.2.1.88 N-ethylmaleimide no inhibition Bos taurus
1.2.1.88 NH2OH
-
 Bos taurus
1.2.1.88 p-hydroxymercuribenzoate
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.88 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.88 additional information
-
-
 Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.2.1.88 -15°C, 50% loss of activity, 2 months Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.88 1-pyrroline-5-carboxylate + NAD+ + H2O
-
 Bos taurus L-glutamate + NADH
-
 ir
1.2.1.88 DELTA1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O
-
 Bos taurus 4-hydroxyglutamate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.88 8.5 8.6
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.88 7.4 9.4
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.88 NAD+ preferentially Bos taurus
1.2.1.88 NADP+
-
 Bos taurus