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Literature summary extracted from

  • Lundgren, D.W.; Ogur, M.
    Inhibition of yeast 1 -pyrroline-5-carboxylate dehydrogenase by common amino acids and the regulation of proline catabolism (1973), Biochim. Biophys. Acta, 297, 246-257.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.88 D-Ala
-
 Saccharomyces sp.
1.2.1.88 Gly
-
 Saccharomyces sp.
1.2.1.88 L-Ala
-
 Saccharomyces sp.
1.2.1.88 L-Asp
-
 Saccharomyces sp.
1.2.1.88 L-Glu
-
 Saccharomyces sp.
1.2.1.88 L-His
-
 Saccharomyces sp.
1.2.1.88 L-Ile
-
 Saccharomyces sp.
1.2.1.88 L-Leu
-
 Saccharomyces sp.
1.2.1.88 L-Ser
-
 Saccharomyces sp.
1.2.1.88 L-Trp
-
 Saccharomyces sp.
1.2.1.88 L-Val
-
 Saccharomyces sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.88 0.35
-
 1-pyrroline-5-carboxylate
-
 Saccharomyces sp.

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Saccharomyces sp.
-
 glutamate auxotroph
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.88 1-pyrroline-5-carboxylate + NAD+ + H2O
-
 Saccharomyces sp. L-glutamate + NADH + H+
-
 r