Any feedback?
Literature summary extracted from
- Amine oxidases from Aspergillus niger: identification of a novel flavin-dependent enzyme (1995), Biochim. Biophys. Acta, 1243, 529-537.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.4 | Clorgyline | - |
Aspergillus niger |  |
| 1.4.3.4 | Deprenyl | - |
Aspergillus niger | |
| 1.4.3.4 | Pargyline | - |
Aspergillus niger | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.22 | 0.1 | - |
tryptamine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.12 | - |
tyramine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.12 | - |
2-Phenylethylamine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.14 | - |
1,4-methylhistamine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.2 | - |
aminohexane | - |
Aspergillus niger | |
| 1.4.3.22 | 0.24 | - |
benzylamine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.29 | - |
serotonin | - |
Aspergillus niger | |
| 1.4.3.22 | 0.35 | - |
aminopentane | - |
Aspergillus niger | |
| 1.4.3.22 | 0.36 | - |
octopamine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.6 | - |
dopamine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.6 | - |
histamine | - |
Aspergillus niger | |
| 1.4.3.22 | 0.6 | - |
aminobutane | - |
Aspergillus niger | |
| 1.4.3.22 | 1.05 | - |
norepinephrine | - |
Aspergillus niger | |
| 1.4.3.22 | 1.6 | - |
Aminopropane | - |
Aspergillus niger | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.4.3.4 | 55000 | - |
4 * 55000, SDS-PAGE | Aspergillus niger |
| 1.4.3.4 | 215000 | - |
gel filtration | Aspergillus niger |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | Aspergillus niger | - |
two amine oxidases isolated: the first one corresponds to the copper-dependent enzyme, the second one is an evolutionary prototype form of MAO-A and B | - |
| 1.4.3.22 | Aspergillus niger | Q12556 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.4.3.4 | - |
Aspergillus niger |
| 1.4.3.22 | - |
Aspergillus niger |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | mycelium | - |
Aspergillus niger | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.4.3.22 | 45400 | - |
- |
Aspergillus niger |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.4.3.4 | -20°C, stable for several weeks | Aspergillus niger |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.4 | 2-phenylethylamine + H2O + O2 | - |
Aspergillus niger | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | benzylamine + H2O + O2 | - |
Aspergillus niger | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | dopamine + H2O + O2 | - |
Aspergillus niger | (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | RCH2NH2 + H2O + O2 | no activity with histamine | Aspergillus niger | RCHO + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | RCH2NH2 + H2O + O2 | norepinephrine | Aspergillus niger | RCHO + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | RCH2NH2 + H2O + O2 | no activity with octopamine | Aspergillus niger | RCHO + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | serotonin + H2O + O2 | - |
Aspergillus niger | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | 1,4-methylhistamine + H2O + O2 | - |
Aspergillus niger | ? | - |
? | |
| 1.4.3.22 | 2-(3,4-dihydroxyphenyl)-ethylamine + H2O + O2 | - |
Aspergillus niger | 3,4-dihydroxyphenylacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | 2-phenylethylamine + H2O + O2 | - |
Aspergillus niger | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | aminobutane + H2O + O2 | - |
Aspergillus niger | butanal + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | aminohexane + H2O + O2 | - |
Aspergillus niger | hexanal + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | aminopentane + H2O + O2 | - |
Aspergillus niger | pentanal + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | aminopropane + H2O + O2 | - |
Aspergillus niger | propanal + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | benzylamine + H2O + O2 | - |
Aspergillus niger | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | histamine + H2O + O2 | - |
Aspergillus niger | (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | norepinephrine + H2O + O2 | - |
Aspergillus niger | ? | - |
? | |
| 1.4.3.22 | octopamine + H2O + O2 | - |
Aspergillus niger | ? | - |
? | |
| 1.4.3.22 | RCH2NH2 + H2O + O2 | - |
Aspergillus niger | RCHO + NH3 + H2O2 | - |
? | |
| 1.4.3.22 | serotonin + H2O + O2 | - |
Aspergillus niger | ? | - |
? | |
| 1.4.3.22 | tryptamine | - |
Aspergillus niger | ? | - |
? | |
| 1.4.3.22 | tyramine + H2O + O2 | - |
Aspergillus niger | 4-hydroxyphenylethanal + NH3 + H2O2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | tetramer | 4 * 55000, SDS-PAGE | Aspergillus niger |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.22 | 37 | - |
benzylamine | - |
Aspergillus niger | |
| 1.4.3.22 | 65 | - |
norepinephrine | - |
Aspergillus niger | |
| 1.4.3.22 | 68 | - |
1,4-methylhistamine | - |
Aspergillus niger | |
| 1.4.3.22 | 80 | - |
tyramine | - |
Aspergillus niger | |
| 1.4.3.22 | 95 | - |
histamine | - |
Aspergillus niger | |
| 1.4.3.22 | 100 | - |
tryptamine | - |
Aspergillus niger | |
| 1.4.3.22 | 122 | - |
octopamine | - |
Aspergillus niger | |
| 1.4.3.22 | 132 | - |
Aminopropane | - |
Aspergillus niger | |
| 1.4.3.22 | 132 | - |
aminobutane | - |
Aspergillus niger | |
| 1.4.3.22 | 135 | - |
dopamine | - |
Aspergillus niger | |
| 1.4.3.22 | 136 | - |
serotonin | - |
Aspergillus niger | |
| 1.4.3.22 | 137 | - |
2-Phenylethylamine | - |
Aspergillus niger | |
| 1.4.3.22 | 142 | - |
aminopentane | - |
Aspergillus niger | |
| 1.4.3.22 | 159 | - |
aminohexane | - |
Aspergillus niger | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.4 | flavin | noncovalently bound flavin | Aspergillus niger | |
| 1.4.3.22 | 2,4,5-trihydroxyphenylalanine quinone | - |
Aspergillus niger | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
