Literature summary extracted from

  • Bieganski, T.; Kusche, J.; Lorenz, W.; Hesterberg, R.; Stahlknecht, C.D.; Feussner, K.D.
    Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism (1983), Biochim. Biophys. Acta, 756, 196-203.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.22 aminoguanidine
-
Canis lupus familiaris
1.4.3.22 aminoguanidine
-
Cavia porcellus
1.4.3.22 aminoguanidine 0.00001 mM, 50% inhibition, putrescine or histamine as substrates Homo sapiens
1.4.3.22 aminoguanidine
-
Mus musculus
1.4.3.22 aminoguanidine
-
Oryctolagus cuniculus
1.4.3.22 aminoguanidine
-
Rattus norvegicus
1.4.3.22 aminoguanidine
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.22 0.083
-
putrescine
-
Homo sapiens
1.4.3.22 0.097
-
N(tau)-methylhistamine
-
Homo sapiens
1.4.3.22 0.019
-
histamine
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.22 particle-bound
-
Cavia porcellus
-
-
1.4.3.22 mitochondrion mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Mus musculus
-
-
1.4.3.22 mitochondrion mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Homo sapiens
-
-
1.4.3.22 mitochondrion mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Rattus norvegicus
-
-
1.4.3.22 cytoplasm
-
Sus scrofa
-
-
1.4.3.22 cytoplasm
-
Canis lupus familiaris
-
-
1.4.3.22 cytoplasm mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Mus musculus
-
-
1.4.3.22 cytoplasm mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Homo sapiens
-
-
1.4.3.22 cytoplasm mainly in cytoplasm but to a considerable extent also in mitochondrial fraction Rattus norvegicus
-
-
1.4.3.22 cytoplasm chiefly in cytoplasm Mus musculus
-
-
1.4.3.22 cytoplasm chiefly in cytoplasm Rattus norvegicus
-
-
1.4.3.22 cytoplasm chiefly in cytoplasm Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.22 RCH2NH2 + H2O + O2 Rattus norvegicus
-
RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 Cavia porcellus enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 Mus musculus enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 Homo sapiens enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 Sus scrofa enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 Oryctolagus cuniculus enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 Canis lupus familiaris enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis RCHO + NH3 + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Canis lupus familiaris
-
-
-
1.4.3.22 Cavia porcellus
-
-
-
1.4.3.22 Oryctolagus cuniculus
-
-
-
1.4.3.22 Homo sapiens
-
-
-
1.4.3.22 Mus musculus
-
-
-
1.4.3.22 Rattus norvegicus
-
-
-
1.4.3.22 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.22
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.22 colonic mucosa
-
Oryctolagus cuniculus
-
1.4.3.22 colonic mucosa
-
Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.22 0.012
-
-
Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.4.3.22 -20°C, 24 h, 90% loss of activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 RCH2NH2 + H2O + O2
-
Cavia porcellus RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2
-
Mus musculus RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2
-
Rattus norvegicus RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2
-
Sus scrofa RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2
-
Oryctolagus cuniculus RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2
-
Canis lupus familiaris RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 short-chain aliphatic diamines are deaminated with highest reaction velocity Homo sapiens RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Cavia porcellus RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Mus musculus RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Homo sapiens RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Sus scrofa RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Oryctolagus cuniculus RCHO + NH3 + H2O2
-
?
1.4.3.22 RCH2NH2 + H2O + O2 enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis Canis lupus familiaris RCHO + NH3 + H2O2
-
?
1.4.3.22 histamine + H2O + O2
-
Homo sapiens (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
?
1.4.3.22 histamine + H2O + O2
-
Sus scrofa (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
?
1.4.3.22 1,4-diaminobutane + H2O + O2
-
Homo sapiens 4-aminobutanal + NH3 + H2O2
-
?
1.4.3.22 1,4-diaminobutane + H2O + O2
-
Sus scrofa 4-aminobutanal + NH3 + H2O2
-
?
1.4.3.22 1,5-diaminopentane + H2O + O2
-
Homo sapiens 5-aminopentanal + NH3 + H2O2
-
?
1.4.3.22 1,5-diaminopentane + H2O + O2
-
Sus scrofa 5-aminopentanal + NH3 + H2O2
-
?
1.4.3.22 N(tau)-methylhistamine + H2O + O2
-
Homo sapiens ?
-
?
1.4.3.22 2-methylhistamine + H2O + O2
-
Homo sapiens ?
-
?
1.4.3.22 N(pi)-methylhistamine + H2O + O2
-
Homo sapiens ?
-
?
1.4.3.22 5-methylhistamine + H2O + O2
-
Homo sapiens ?
-
?
1.4.3.22 1,6-diaminohexane + H2O + O2
-
Homo sapiens 6-aminohexanal + NH3 + H2O2
-
?
1.4.3.22 1,7-diaminoheptane + H2O + O2
-
Homo sapiens 7-aminoheptanal + NH3 + H2O2
-
?
1.4.3.22 1,2-diaminoethane + H2O + O2
-
Homo sapiens 2-aminoethanal + NH3 + H2O2
-
?
1.4.3.22 1,3-diaminopropane + H2O + O2
-
Homo sapiens 3-aminopropanal + NH3 + H2O2
-
?
1.4.3.22 1,8-diaminooctane + H2O + O2
-
Homo sapiens 8-aminooctanal + NH3 + H2O2
-
?
1.4.3.22 1,9-diaminononane + H2O + O2
-
Homo sapiens 9-aminononanal + NH3 + H2O2
-
?
1.4.3.22 1,10-diaminodecane + H2O + O2
-
Homo sapiens 10-aminodecanal + NH3 + H2O2
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.22 6.6 7 putrescine Homo sapiens
1.4.3.22 6.4 6.6 histamine Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.4.3.22 6.2 7.8 pH 6.2 and pH 7.8: about 75% activity, putrescine Homo sapiens