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Literature summary extracted from

  • Carper, W.R.; Stoddard, D.D.; Martin, D.F.
    Pig liver monoamine oxidase I: isolation and characterization (1974), Biochim. Biophys. Acta, 334, 287-296.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.3.21
-
 Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.21 1,4-phenanthroline 0.33 mM, 65% inhibition Sus scrofa
1.4.3.21 diethyldithiocarbamate 3.3 mM, 74% inhibition Sus scrofa
1.4.3.21 hydroxylamine 3.3 mM, 30% inhibition Sus scrofa
1.4.3.21 NaN3 3.3 mM, 48% inhibition Sus scrofa
1.4.3.21 Neocuproine 0.033 mM, 61% inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.21 0.00128
-
 benzylamine at pH 9.0 Sus scrofa
1.4.3.21 0.0174
-
 benzylamine at pH 7.2 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.21 Co2+ can replace Cu2+ in the enzyme Sus scrofa
1.4.3.21 copper contains 8 Cu2+ per 1200000 Da, Co2+, Zn2+ and Ni2+ can replace Cu2+, no effect of Mn2+ Sus scrofa
1.4.3.21 copper copper protein Sus scrofa
1.4.3.21 Ni2+ can replace Cu2+ in the enzyme Sus scrofa
1.4.3.21 Zn2+ can replace Cu2+ in the enzyme Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.21 146000
-
 8 * 146000 Sus scrofa
1.4.3.21 1200000
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.21 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.21 kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.21 additional information
-
 1100.0-1200.0 units/mg, 1 unit is defined as the amount of enzyme catalyzing a change of 0.001 absorbance per minute at 25°C Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.21 benzylamine + H2O + O2
-
 Sus scrofa benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 RCH2NH2 + H2O + O2
-
 Sus scrofa RCHO + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.21 octamer 8 * 146000 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.21 40
-
-
 Sus scrofa

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.4.3.21 20 40 relative activity at 20°C: 22.8, at 40°C: 31.2 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.21 9
-
 50 mM glycine, 1 mM EDTA Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.4.3.21 6 10
-
 Sus scrofa