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Literature summary extracted from
- Glutathione reductase and glutamate dehydrogenase of Plasmodium falciparum, the causative agent of tropical malaria (1996), Eur. J. Biochem., 235, 345-350.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | medicine | potential target for chemotherapy | Plasmodium falciparum |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 110000 | - |
gel filtration | Plasmodium falciparum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.1.4 | L-glutamate + NADP+ + H2O | Plasmodium falciparum | - |
2-oxoglutarate + NADPH + NH3 | - |
r |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.1.4 | Plasmodium falciparum | - |
- |
- |
| 1.8.1.7 | Plasmodium falciparum | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.4.1.4 | co-purification with glutathione disulfide reductase | Plasmodium falciparum |
| 1.8.1.7 | - |
Plasmodium falciparum |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.4.1.4 | 74.5 | - |
oxidative deamination at pH 7.0 and 70°C | Plasmodium falciparum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.1.4 | L-glutamate + NADP+ + H2O | - |
Plasmodium falciparum | 2-oxoglutarate + NADPH + NH3 | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Plasmodium falciparum | glutathione + NADP+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.4.1.4 | hexamer | - |
Plasmodium falciparum |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | glutathione disulfide reductase | - |
Plasmodium falciparum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 6.8 | - |
- |
Plasmodium falciparum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.1.4 | NADP+ | - |
Plasmodium falciparum | |
| 1.4.1.4 | NADPH | - |
Plasmodium falciparum | |
| 1.8.1.7 | FAD | FAD enzyme | Plasmodium falciparum | |
| 1.8.1.7 | NADH | low activity with NADH | Plasmodium falciparum | |
| 1.8.1.7 | NADPH | can utilize both NADPH and NADH, more active with NADPH | Plasmodium falciparum | |
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