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Literature summary extracted from

  • Rajas, F.; Rousset, B.
    A membrane-bound form of glutamate dehydrogenase possesses an ATP-dependent high-affinity microtubule-binding activity (1993), Biochem. J., 295, 447-455.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.1.3 ADP
-
Rattus norvegicus
1.4.1.3 ADP
-
Bos taurus
1.4.1.3 ADP 1 mM, approx. 2fold activation of membrane-bound liver enzyme Sus scrofa
1.4.1.3 ATP
-
Rattus norvegicus
1.4.1.3 ATP
-
Bos taurus
1.4.1.3 ATP approx. 1.5fold activation of membrane-bound liver enzyme Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.3 ATP
-
Bos taurus
1.4.1.3 ATP membrane-bound enzyme form, inhibition of microtubule-binding activity Sus scrofa
1.4.1.3 GTP
-
Bos taurus
1.4.1.3 GTP
-
Rattus norvegicus
1.4.1.3 GTP membrane-bound liver enzyme, complete inhibition Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.1.3 membrane peripheral membrane protein Sus scrofa 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.1.3 50000
-
6 * 50000, membrane-bound liver enzyme, SDS-PAGE Sus scrofa
1.4.1.3 330000
-
membrane-bound liver enzyme, velocity sedimentation on sucrose density gradient Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.3 Bos taurus
-
-
-
1.4.1.3 Rattus norvegicus
-
-
-
1.4.1.3 Sus scrofa
-
membrane-bound enzyme exhibits microtubule-binding activity
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.1.3 affinity-purified Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.1.3 brain
-
Rattus norvegicus
-
1.4.1.3 brain
-
Sus scrofa
-
1.4.1.3 brain
-
Bos taurus
-
1.4.1.3 liver
-
Rattus norvegicus
-
1.4.1.3 liver
-
Sus scrofa
-
1.4.1.3 liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.1.3 4.6
-
membrane-bound liver enzyme Sus scrofa
1.4.1.3 17.8
-
liver enzyme Rattus norvegicus
1.4.1.3 34
-
liver enzyme Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.3 L-glutamate + H2O + NAD(P)+
-
Rattus norvegicus 2-oxoglutarate + NH3 + NAD(P)H
-
r
1.4.1.3 L-glutamate + H2O + NAD(P)+
-
Sus scrofa 2-oxoglutarate + NH3 + NAD(P)H
-
r
1.4.1.3 L-glutamate + H2O + NAD(P)+
-
Bos taurus 2-oxoglutarate + NH3 + NAD(P)H
-
r

Subunits

EC Number Subunits Comment Organism
1.4.1.3 hexamer 6 * 50000, membrane-bound liver enzyme, SDS-PAGE Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.1.3 0.76
-
ATP inhibition of microtubules to membrane-bound liver enzyme Sus scrofa