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Literature summary extracted from

  • Di Prisco, G.
    Effect of pH and ionic strength on the catalytic and allosteric properties of native and chemically modified ox liver mitochondrial glutamate dehydrogenase (1975), Arch. Biochem. Biophys., 171, 604-612.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.1.3 ADP above pH 7.0: allosteric activation Bos taurus
1.4.1.3 ADP pH 6.0-7.0: strong inhibition Bos taurus
1.4.1.3 GTP inhibition at pH 9.0, activation in presence of electrolytes at pH 6.0 Bos taurus
1.4.1.3 phosphate activator at pH 8.0-9.0, inhibitor at pH 6.0-7.6 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.3 ADP above pH 7.0: allosteric activation, pH 6.0-7.0: strong inhibition Bos taurus
1.4.1.3 GTP inhibition at pH 9.0, activation in presence of electrolytes at pH 6.0 Bos taurus
1.4.1.3 phosphate pH 8.0-9.0: activation, pH 6.0-7.6: almost complete inhibition with 400 mM Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.3 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.3 L-glutamate + H2O + NAD(P)+
-
 Bos taurus 2-oxoglutarate + NH3 + NAD(P)H
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.1.3 7.6
-
 in the absence of phosphate Bos taurus
1.4.1.3 9
-
 in the presence of 330 mM phosphate Bos taurus